Description
protein arginine methyltransferase 6(PRMT6) Homo sapiens. The protein encoded by this gene belongs to the arginine N-methyltransferase family, which catalyze the sequential transfer of methyl group from S-adenosyl-L-methionine to the side chain nitrogens of arginine residues within proteins, to form methylated arginine derivatives and S-adenosyl-L-homocysteine. This protein can catalyze both, the formation of omega-N monomethylarginine and asymmetrical dimethylarginine, with a strong preference for the latter. It specifically mediates the asymmetric dimethylation of Arg2 of histone H3, and the methylated form represents a specific tag for epigenetic transcriptional repression. This protein also forms a complex with, and methylates DNA polymerase beta, resulting in stimulation of polymerase activity by enhancing DNA binding and processivity. [provided by RefSeq, Sep 2011],
Reactivity
Human
Applications
WB,IHC,ICC
Modification
Unmodfied/ Total
Source
Monoclonal Mouse
Dilution
wb 1:1000 icc 1:300
Purification
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Storage and Stability
-20°C/1 year
Other Name
ANM6_HUMAN;Chromobox protein homolog 7;FLJ10559;FLJ51477;Heterogeneous nuclear ribonucleoprotein methyltransferase like protein 6;Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 6;Histone-arginine N-methyltransferase PRMT6;HMT1 hnRNP methyltransferase like 6.;HRMT1L6;OTTHUMP00000012633;PRMT 6;prmt6; Protein arginine methyltransferase 6;Protein arginine N methyltransferase 6;Protein arginine N-methyltransferase 6.
Molecular Weight (Da)
Gene Name
prmt6
Protein Name
Human Gene ID
55170
Human Swiss Prot No.
Q96LA8
Immunogen
Purified recombinant human PRMT6 protein fragments expressed in E.coli.
Specificity
This antibody detects endogenous levels of PRMT6 and does not cross-react with related proteins.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
