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Primary Antibodies
Anti-Human Topoisomerase IIα (ABT272) Mouse Monoclonal Antibody
Anti-Human Topoisomerase IIα (ABT272) Mouse Monoclonal Antibody

Assay Biotechnology Inc Antibodies and ELISA Kits have been rigorously validated for laboratory grade quality results. High specificity paired with high affinity for targets of interest give researchers an advantage with our products

Catalog No: V0466
Reactivity:Human
Application:IHC
Modification:Unmodified/ Total
Source:Monoclonal Mouse
Storage and Stability:Stable at -20°C for at least 1 year.

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Immunohistochemical
Sample Sized mAbs 5477
Pathology Grade Abs
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Anti-Human Topoisomerase IIα (ABT272) Mouse Monoclonal Antibody

Human lung squamous cell carcinoma tissue was stained with Anti-Topoisomerase IIα (ABT272) Antibody

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Product Details
Product Name
Anti-Human Topoisomerase IIα (ABT272) Mouse Monoclonal Antibody
Description
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also pla
Catalog No
V0466
Reactivity
Human
Application
IHC
Modification
Unmodified/ Total
Source
Monoclonal Mouse
Storage and Stability
Stable at -20°C for at least 1 year.
Other Name
alpha isozyme, ATP hydrolyzing DNA topoisomerase II alfa, DNA gyrase, DNA topoisomerase (ATP hydrolyzing), DNA topoisomerase 2 alpha, DNA topoisomerase 2-alpha, DNA topoisomerase II 170 kD, DNA topoisomerase II alpha isozyme, DNA topoisomerase II, DNA Topoisomerase2, TOP 2A, TOP2, TOP2A, TOP2A_HUMAN, Topoisomerase DNA II alpha 170 kDa, TP2A
Gene Name
TOP2A
UniProtKB
P11388
Clone ID
ABT272
Isotype
IgG1, kappa
Localization
Nuclear
Positive Tissue Control
Tonsil/ Appendix
Specificity
The antibody can specifically recognize human Topoisomerase IIα protein.
Formulation
PBS, pH7.2, 0.03% Proclin 300, 50% glycerol
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Primary Antibodies

    • ELISA Kits

    • Research Areas

    Cell Adhesion Proteins Cell Cycle Proteins Channel Proteins Exosome GDP/GTP Binding Proteins Growth Factors and Hormones Homeodomain Proteins Immunohistochemical Kinases and Phosphatases Signaling

     

    Membrane Receptors Neurobiology Signaling Intermediates Steroid Receptors Structural Proteins Synthesis and Degradation Transcription Regulators Transport and Trafficking Tumor Suppressors/Apoptosis
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