paired box 8(PAX8) Homo sapiens. This gene encodes a member of the paired box (PAX) family of transcription factors. Members of this gene family typically encode proteins that contain a paired box domain, an octapeptide, and a paired-type homeodomain. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas and atypical follicular thyroid adenomas. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Mar 2010],
Catalog No
N0508
Reactivity
Human
Applications
WB,ELISA
Modification
Unmodfied/ Total
Source
Monoclonal Mouse
Dilution
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Purification
Affinity purification
Concentration
Storage and Stability
-20°C/1 year
Other Name
PAX8; Paired box protein Pax-8
Molecular Weight (Da)
Gene Name
PAX8
Protein Name
Paired box protein Pax-8
Human Gene ID
7846
Human Swiss Prot No.
Q06710
Immunogen
Purified recombinant fragment of human Pax-8 expressed in E. Coli.
Specificity
Pax-8 Monoclonal Antibody detects endogenous levels of Pax-8 protein.
