TAB1(N-term) mouse mAb

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Catalog No: N0867

Reactivity:Human

Applications:WB

Modification:Unmodfied/ Total

Source:Monoclonal Mouse

Storage and Stability:-20°C/1 year

Size:

Price/Quantity $160

Quantity:

Datasheet

SDS

Signaling Intermediates

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TAB1(N-term) mouse mAb

Western blot detection of TAB1(N-terminus) in K562 and Hela lysates using TAB1(N-terminus) mouse mAb (1:1000 diluted).Predicted band size: 55KDa.Observed band size: 55KDa.

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Lead Time

Antibodies 1-2 business day, ELISA kits 2-3 business day lead time

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408-747-0185

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408-747-0145

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Product Details

Product Name

TAB1(N-term) mouse mAb

Description

The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced tr

Catalog No

N0867

Reactivity

Human

Applications

Modification

Unmodfied/ Total

Source

Monoclonal Mouse

Dilution

wb 1:1000

Purification

The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Storage and Stability

-20°C/1 year

Other Name

2310012M03Rik;3'-Tab1;MAP3K7IP 1;MAP3K7IP1;MGC57664;Mitogen activated protein kinase kinase kinase 7 interacting protein 1;Mitogen-activated protein kinase kinase kinase 7-interacting protein 1;TAB 1;TAB1;TAB1_HUMAN;TAK1 binding protein 1;TAK1-binding protein 1;TGF beta activated kinase 1 binding protein 1;TGF-beta activated kinase 1/MAP3K7 binding protein 1;TGF-beta-activated kinase 1 and MAP3K7-binding protein 1;TGF-beta-activated kinase 1-binding protein 1;Transforming growth factor beta activated kinase binding protein 1.

Molecular Weight (Da)

Gene Name

tab1

Protein Name

Human Gene ID

10454

Human Swiss Prot No.

Q15750

Immunogen

Purified recombinant human TAB1(N-terminus) protein fragments expressed in E.coli.

Specificity

This antibody detects endogenous levels of TAB1(N-terminus) and does not cross-react with related proteins.