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Primary Antibodies
Caspase-1 Antibody
Caspase-1 Antibody

Assay Biotechnology Inc Antibodies and ELISA Kits have been rigorously validated for laboratory grade quality results. High specificity paired with high affinity for targets of interest give researchers an advantage with our products

Catalog No: C30122
Reactivity:Human,Rat
Applications:IF/ICC,WB,IHC-p,ELISA
Modification:Unmodified/Total
Source:Polyclonal Rabbit
Storage and Stability:-20°C/1 year

$205
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Caspase-1 Antibody

Western Blot analysis of 293T Hela MCF-7 Hela-UV MCF-7-UV KB-UV cells using Caspase-1 Polyclonal Antibody diluted at 1:1000. Secondary antibody(catalogNo.:SA0002) was diluted at 1:20000

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Product Details
Product Name
Caspase-1 Antibody
Description
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Mar 2012]
Catalog No
C30122
Reactivity
Human, Rat
Applications
IF/ICC, WB, IHC-p, ELISA
Modification
Unmodified/Total
Source
Polyclonal Rabbit
Dilution
IF: 1:50-200 WB 1:500-2000, IHC 1:50-300, ELISA 1:10000-20000
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Storage and Stability
-20°C/1 year
Other Name
caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
Molecular Weight (Da)
45159
Gene Name
CASP1 IL1BC IL1BCE
Protein Name
Caspase1
Human Gene ID
834
Human Swiss Prot No.
P29466
Immunogen
The antiserum was produced against synthesized peptide derived from the C-terminal region of human CASP1. AA range:350-400
Specificity
Caspase-1 Polyclonal Antibody detects endogenous levels of Caspase-1
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Publications (9)
Platelet-rich plasma-derived exosomes attenuate intervertebral disc degeneration by promoting NLRP3 autophagic degradation in macrophages

Author: Jun Qian, Xiangdong Wang, Guanghui Su, Xiaolin Shu, Zucheng Huang, Huaji Jiang, Qingan Zhu

Date of Publication : 2022-06-24

Oat fiber supplementation alleviates intestinal inflammation and ameliorates intestinal mucosal barrier via acting on gut microbiota-derived metabolites in LDLR–/– mice

Author: Hui Gao, Rui-Juan Song, Hui Jiang, Weiguo Zhang, Shu-Fen Han

Date of Publication : 2021-11-28

Apple Polyphenols Extract (APE) Alleviated Dextran Sulfate Sodium Induced Acute Ulcerative Colitis and Accompanying Neuroinflammation via Inhibition of Apoptosis and Pyroptosis

Author: Fang Liu, Xinjing Wang, Yuan Cui, Yan Yin, Dong Qiu, Shilan Li, Xinli Li

Date of Publication : 2021-11-05

Folic Acid Alleviates High Glucose and Fat-Induced Pyroptosis via Inhibition of the Hippo Signal Pathway on H9C2 Cells

Author: Lei Hong, Yingjie Zha, Chen Wang, Shigang Qiao, Jianzhong An

Date of Publication : 2021-10-07

Antitumor Effect of Fluoxetine on Chronic Stress-Promoted Lung Cancer Growth via Suppressing Kynurenine Pathway and Enhancing Cellular Immunity

Author: Yang Zhen, Li Zhuman, Guo Zhijun, Ren Yu, Zhou Ting, Xiao Zhijun, Duan Jingjing, Han Chuangchuang, Cheng Yuanchi, Xu Feng

Date of Publication : 2021-08-03

Early changes of NLRP3 inflammasome activation after hypoxic-ischemic brain injury in neonatal rats

Author: Na Li, Chunying Liu, Chunnan Wang, Ruidan Chen, Xiaofeng Li, Yang Wang, Chunyu Wang

Date of Publication : 2021-02-01

Dl-3-n-butylphthalide inhibits neuroinflammation by stimulating foxp3 and Ki-67 in an ischemic stroke model.

Author: Xi Liu, Runzhe Liu, Dongxu Fu, Hao Wu, Xin Zhao, Yi Sun, Meng Wang, Xiaoping Pu

Date of Publication : 2021-01-01

MCC950 Inhibits NLRP3 Inflammasome and Alleviates Axonal Injures in Early Stages of Diffuse Axonal Injury in Rats

Author: Zhao, Junjie, Guo, Xiaoye, Wang, Bo, Yang, Zhongbo, Huang, Tingqin, Guo, Dan, Zhang, Ming, Song, Jinning

Date of Publication : 2020-05-30

Corticosterone Inhibits LPS-Induced NLRP3 Inflammasome Priming in Macrophages by Suppressing Xanthine Oxidase

Author: Wu Ling, Zhou Chengfu, Wu Jianfeng, Chen Shikun, Tian Zedan, Du Quan

Date of Publication : 2020-05-18

Primary Antibodies

    • ELISA Kits

    • Research Areas

    Cell Adhesion Proteins Cell Cycle Proteins Channel Proteins Exosome GDP/GTP Binding Proteins Growth Factors and Hormones Homeodomain Proteins Immunohistochemical Kinases and Phosphatases Signaling

     

    Membrane Receptors Neurobiology Signaling Intermediates Steroid Receptors Structural Proteins Synthesis and Degradation Transcription Regulators Transport and Trafficking Tumor Suppressors/Apoptosis
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