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Primary Antibodies
PERK (Phospho-Thr981) Antibody
PERK (Phospho-Thr981) Antibody

Assay Biotechnology Inc Antibodies and ELISA Kits have been rigorously validated for laboratory grade quality results. High specificity paired with high affinity for targets of interest give researchers an advantage with our products

Catalog No: A8168
Reactivity:Human,Mouse,Rat
Applications:IF/ICC,WB,IHC-p,ELISA
Modification:Phospho Specific
Source:Polyclonal Rabbit
Storage and Stability:-20°C/1 year

$205
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PERK (Phospho-Thr981) Antibody

Western blot analysis of lysates from 1) 453, 2) AD293, 3) Hela cells, （Green） primary antibody was diluted at 1:1000, 4°over night, secondary antibody(cat:SA0439)was diluted at 1:10000, 37° 1hour. （Red） Actin β Monoclonal Antibody(5B7) (cat:N1292) antibody was diluted at 1:5000 as loading control, 4° over night,secondary antibody(cat:SA0436)was diluted at 1:10000, 37° 1hour.

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Product Details
Product Name
PERK (Phospho-Thr981) Antibody
Description
The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome. [provided by RefSeq, Sep 2015]
Catalog No
A8168
Reactivity
Human, Mouse, Rat
Applications
IF/ICC, WB, IHC-p, ELISA
Modification
Phospho Specific
Source
Polyclonal Rabbit
Dilution
IF: 1:50-200 WB 1:500-2000 ,Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Storage and Stability
-20°C/1 year
Other Name
EIF2AK3; PEK; PERK; Eukaryotic translation initiation factor 2-alpha kinase 3; PRKR-like endoplasmic reticulum kinase; Pancreatic eIF2-alpha kinase; HsPEK
Molecular Weight (Da)
125147
Gene Name
EIF2AK3
Protein Name
Eukaryotic translation initiation factor 2-alpha kinase 3
Human Gene ID
9451
Human Swiss Prot No.
Q9NZJ5
Immunogen
The antiserum was produced against synthesized peptide derived from human PEK/PERK around the phosphorylation site of Thr981. AA range:947-996
Specificity
Phospho-PERK (T981) Polyclonal Antibody detects endogenous levels of PERK protein only when phosphorylated at T981.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Publications (14)
Endoplasmic reticulum stress-mediated autophagy activation is involved in cadmium-induced ferroptosis of renal tubular epithelial cells

Author: Caijun Zhao, Duo Yu, Zhaoqi He, Lijuan Bao, Lianjun Feng, Luotong Chen, Zhuoyu Liu, Xiaoyu Hu, Naisheng Zhang, Tiejun Wang, Yunhe Fu

Date of Publication : 2021-09-11

Capecitabine Can Induce T Cell Apoptosis: A Potential Immunosuppressive Agent With Anti-Cancer Effect

Author: Sai Zhang, Zhenglu Wang, Shunli Fan, Tao Liu, Sei Yoshida, Shuang Yang, Lei Liu, Wen Hou, Lei Cao, Jianxi Wang, Zhuolun Song, Shanni Li, Sirui Zhang, Hao Wang, Jianghong Li, Hong Zheng, Zhongyang Shen

Date of Publication : 2021-09-07

Effect of Gegen Qinlian Decoction on Hepatic Gluconeogenesis in ZDF Rats with Type 2 Diabetes Mellitus Based on the Farnesol X Receptor/Ceramide Signaling Pathway Regulating Mitochondrial Metabolism and Endoplasmic Reticulum Stress

Author: Zhou Qi, Song Ning, Wang Shi-qi, Wang Yan, Zhao Yi-kun, Zhu Xiang-dong

Date of Publication : 2021-08-10

Citrus alkaline extracts prevent endoplasmic reticulum stress in type II alveolar epithelial cells to ameliorate pulmonary fibrosis via the ATF3/PINK1 pathway

Author: Zhichao Wang, Fanchao Feng, Hailang He, Qi Wu, Cheng Gu, Jonathan Hrovat, Wenpan Peng, Yong Xu, Di Han, Ping Yang, Xianmei Zhou, Jianxin Li, Jinjun Shan

Date of Publication : 2021-05-21

Glucocorticoids protect HEI-OC1 cells from tunicamycin-induced cell damage via inhibiting endoplasmic reticulum stress

Author: Zhibiao Liu, Bing Fei, Lisheng Xie, Jin Liu, Xiaorui Chen, Wenyan Zhu, Lingyun Lv, Wei Ma, Ziwen Gao, Jie Hou, Wandong She

Date of Publication : 2021-01-01

Differential Levels of Endoplasmic Reticulum Stress in Peripheral Blood Mononuclear Cells from Patients with Sudden Sensorineural Hearing Loss

Author: Zhibiao Liu, Bing Fei, Xiaoping Du, Yanhong Dai, Wandong She

Date of Publication : 2020-11-10

Limonin ameliorates dextran sulfate sodium-induced chronic colitis in mice by inhibiting PERK-ATF4-CHOP pathway of ER stress and NF-κB signaling

Author: Changqin Song, Jiaxi Chen, Xiaotian Li, Runyu Yang, Xiaomei Cao, Lvqi Zhou, Yanfen Zhou, Hanjie Ying, Qi Zhang, Yang Sun

Date of Publication : 2020-11-07

NLRP3 inflammasome and endoplasmic reticulum stress in the epileptogenic zone in temporal lobe epilepsy: molecular insights into their interdependence

Author: J. Yue, Y. J. Wei, X. L. Yang, S. Y. Liu, H. Yang, C. ‐Q. Zhang

Date of Publication : 2020-05-08

The Regulatory Effect of VEGF-Ax on Rat Bone Marrow Mesenchymal Stem Cells' Angioblastic Differentiation and Its Proangiogenic Ability

Author: Jianjun Li, Zhihao Li, Chengqiang Wang, Zhijia Li, Haixia Xu, Yunteng Hu, Zhiwen Tan, Fu Zhang, Chun Liu, Minsheng Yang, Yihan Wang, Yanglei Jin, Ziyue Peng, Sourabh Biswas, Lixin Zhu

Date of Publication : 2020-05-06

Microcystin-LR ameliorates pulmonary fibrosis via modulating CD206 + M2-like macrophage polarization

Author: Wang, Jie, Xu, Lizhi, Xiang, Zou, Ren, Yan, Zheng, Xiufen, Zhao, Qingya, Zhou, Qunzhi, Zhou, Yuefen, Xu, Lin, Wang, Yaping

Date of Publication : 2020-02-19

Erythropoietin suppresses hepatic steatosis and obesity by inhibiting endoplasmic reticulum stress and upregulating fibroblast growth factor 21

Author: Ting Hong, Zhijuan Ge, Bingjie Zhang, Ran Meng, Dalong Zhu, Yan Bi

Date of Publication : 2019-08-01

Endoplasmic Reticulum Stress in Spinal Cord Contributes to the Development of Morphine Tolerance

Author: Liu Daiqiang, Zhou Yaqun, Peng Yawen, Su Peng, Li Zheng, Xu Qiaoqiao, Tu Ye, Tian Xuebi, Yang Hui, Wu Zhen, Mei Wei, Gao Feng

Date of Publication : 2018-03-06

PERK signalling pathway mediates single prolonged stress-induced dysfunction of medial prefrontal cortex neurons

Author: Lili Wen, Bing Xiao, Yuxiu Shi, Fang Han

Date of Publication : 2017-04-08

Recombinant Newcastle disease virus (rL-RVG) triggers autophagy and apoptosis in gastric carcinoma cells by inducing ER stress

Author: Xuefeng Bu, Yinghai Zhao, Zhijian Zhang, Mubin Wang, Mi Li, Yulan Yan

Date of Publication : 2016-05-01

Primary Antibodies

    • ELISA Kits

    • Research Areas

    Cell Adhesion Proteins Cell Cycle Proteins Channel Proteins Exosome GDP/GTP Binding Proteins Growth Factors and Hormones Homeodomain Proteins Immunohistochemical Kinases and Phosphatases Signaling

     

    Membrane Receptors Neurobiology Signaling Intermediates Steroid Receptors Structural Proteins Synthesis and Degradation Transcription Regulators Transport and Trafficking Tumor Suppressors/Apoptosis
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