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PERK (Phospho-Thr981) Antibody
PERK (Phospho-Thr981) Antibody

Assay Biotechnology Inc Antibodies and ELISA Kits have been rigorously validated for laboratory grade quality results. High specificity paired with high affinity for targets of interest give researchers an advantage with our products

Catalog No: A8168
Reactivity:Human,Mouse,Rat
Applications:IF,WB,IHC,ELISA
Modification:Phospho Specific
Source:Store at -20°C/1 year
Storage and Stability:

$205
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Kinases and Phosphatases
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PERK (Phospho-Thr981) Antibody

Enzyme-Linked Immunosorbent Assay (Phospho-ELISA) for Immunogen Phosphopeptide (Phospho-left) and Non-Phosphopeptide (Phospho-right), using PEK/PERK (Phospho-Thr981) Antibody

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Product Details
Product Name
PERK (Phospho-Thr981) Antibody
Description
The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome. [provided by RefSeq, Sep 2015],
Catalog No
A8168
Reactivity
Human, Mouse, Rat
Source
Polyclonal, Rabbit,IgG
Modification
Phospho Specific
Applications
IF, WB, IHC, ELISA
Dilution
IF 1:50-200 WB 1:500-2000 ,IHC 1:100 - 1:300. ELISA: 1:40000. Not yet tested in other applications.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Storage and Stability
Store at -20°C/1 year
Other Name
EIF2AK3; PEK; PERK; Eukaryotic translation initiation factor 2-alpha kinase 3; PRKR-like endoplasmic reticulum kinase; Pancreatic eIF2-alpha kinase; HsPEK
Molecular Weight (Da or kDa)
Gene Name
EIF2AK3
Protein Name
Eukaryotic translation initiation factor 2-alpha kinase 3
Human Gene ID
9451
Human Swiss Prot No.
Q9NZJ5
Immunogen
The antiserum was produced against synthesized peptide derived from human PEK/PERK around the phosphorylation site of Thr981. AA range:947-996
Specificity
Phospho-PERK (T981) Polyclonal Antibody detects endogenous levels of PERK protein only when phosphorylated at T981.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Publications (21)
Valdecoxib Protects against Cell Apoptosis Induced by Endoplasmic Reticulum Stress via the Inhibition of PERK-ATF4-CHOP Pathway in Experimental Glaucoma

Author: Available in link provided

Date of Publication : Available in link provided

Microcystin-LR ameliorates pulmonary fibrosis via modulating CD206 + M2-like macrophage polarization. Cell Death & Disease Cell Death Dis. 2020 Feb;11(2):1-15 WB Mouse,Rat pulmonary tissues RAW264.7 cell

Author: Available in link provided

Date of Publication : Available in link provided

Recombinant Newcastle disease virus (rL-RVG) triggers autophagy and apoptosis in gastric carcinoma cells by inducing ER stress. American Journal of Cancer Research Am J Cancer Res. 2016; 6(5): 924–936 WB Human SGC-7901 cell, HGC cell

Author: Available in link provided

Date of Publication : Available in link provided

Endoplasmic Reticulum Stress in Spinal Cord Contributes to the Development of Morphine Tolerance. Frontiers in Molecular Neuroscience Front Mol Neurosci. 2018 Mar;11:72 IHC Rat 1:50 spinal dorsal horn

Author: Available in link provided

Date of Publication : Available in link provided

Citrus alkaline extracts prevent endoplasmic reticulum stress in type II alveolar epithelial cells to ameliorate pulmonary fibrosis via the ATF3/PINK1 pathway. PHYTOMEDICINE Phytomedicine. 2021 Aug;89:153599 WB Human 1 : 1000 Lung A549 cell

Author: Available in link provided

Date of Publication : Available in link provided

Stress kinases, endoplasmic reticulum stress, and Alzheimer’s disease related markers in peripheral blood mononuclear cells from subjects with increased body weight. Scientific Reports 2016 Aug 02 WB Human PBMCs

Author: Available in link provided

Date of Publication : Available in link provided

PERK signalling pathway mediates single prolonged stress-induced dysfunction of medial prefrontal cortex neurons. APOPTOSIS Apoptosis. 2017 Jun;22(6):753-768 WB Rat 1:500 neurons

Author: Available in link provided

Date of Publication : Available in link provided

Limonin ameliorates dextran sulfate sodium-induced chronic colitis in mice by inhibiting PERK-ATF4-CHOP pathway of ER stress and NF-κB signaling. INTERNATIONAL IMMUNOPHARMACOLOGY Int Immunopharmacol. 2021 Jan;90:107161 IHC Mouse Colon

Author: Available in link provided

Date of Publication : Available in link provided

Glucocorticoids protect HEI-OC1 cells from tunicamycin-induced cell damage via inhibiting endoplasmic reticulum stress. Open Life Sciences Open Life Sci. 2021 Jan;16(1):695-702 WB Mouse 1 : 1000 HEI-OC1 Cell

Author: Available in link provided

Date of Publication : Available in link provided

Chlamydia trachomatis plasmid-encoded protein pORF5 activates unfolded protein response to induce autophagy via MAPK/ERK signaling pathway. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2020 May 20 WB Human HeLa cell

Author: Available in link provided

Date of Publication : Available in link provided

Isorhamnetin protects against bleomycin-induced pulmonary fibrosis by inhibiting endoplasmic reticulum stress and epithelial-mesenchymal transition. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 2019 Jan 01 WB Human,Mouse 1:2000 lung A549 cell,HBECs

Author: Available in link provided

Date of Publication : Available in link provided

Rce1 expression in renal cell carcinoma and its regulatory effect on 786-O cell apoptosis through endoplasmic reticulum stress. ACTA BIOCHIMICA ET BIOPHYSICA SINICA 2017 Mar 01 WB Human 1:2000 renal cancer tissues 786-O cell

Author: Available in link provided

Date of Publication : Available in link provided

Cheng, Jinbo, et al. "Vitamin D combined with resveratrol prevents cognitive decline in SAMP8 mice." Current Alzheimer Research 14.8 (2017): 820-833.

Author: Available in link provided

Date of Publication : Available in link provided

Cadmium induces liver dysfunction and ferroptosis through the endoplasmic stress-ferritinophagy axis ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY Jiacheng Wu WB Mouse

Author: Available in link provided

Date of Publication : Available in link provided

ROS Scavenging Nanozyme Modulates Immunosuppression for Sensitized Cancer Immunotherapy Advanced Healthcare Materials Hui Wei WB Mouse bone marrow-derived macrophages (BMDMs),Myeloid-derived suppressor cells (MDSCs)

Author: Available in link provided

Date of Publication : Available in link provided

Downregulation of RCN1 promotes pyroptosis in acute myeloid leukemia cells. Molecular Oncology Qiaoxia Zhang WB Human OCI/AML3 cell,NB4 cell

Author: Available in link provided

Date of Publication : Available in link provided

Apigenin-induced Apoptosis is Reduced via Endoplasmic Reticulum Stress and ATF6/PERK Signaling in Human Gastric Cancer Cells. Pharmacognosy Magazine Liying Hou WB Human SGC-7901 Cell

Author: Available in link provided

Date of Publication : Available in link provided

ETV2 regulating PHD2-HIF-1α axis controls metabolism reprogramming promotes vascularized bone regeneration Bioactive Materials HaoRan Du WB,IF Human 1:1000,1:100 dental pulp stem cells (DPSCs)

Author: Available in link provided

Date of Publication : Available in link provided

Rolapitant treats lung cancer by targeting deubiquitinase OTUD3 Cell Communication and Signaling Du Tongde WB Human A549 cell,H1299 cell

Author: Available in link provided

Date of Publication : Available in link provided

Dietary bitter ginger-derived zerumbone improved memory performance during aging through inhibition of the PERK/CHOP-dependent endoplasmic reticulum stress pathway Food & Function Chuan Yang WB Mouse,Human brain tissue SH-SY5Y cell

Author: Available in link provided

Date of Publication : Available in link provided

Ferroptosis is involved in Staphylococcus aureus-induced mastitis through autophagy activation by endoplasmic reticulum stress INTERNATIONAL IMMUNOPHARMACOLOGY Lijuan Bao WB Mouse 1:1000 Mouse mammary epithelial cell(MMEC)

Author: Available in link provided

Date of Publication : Available in link provided

Primary Antibodies

    • ELISA Kits

    • Research Areas

    Cell Adhesion Proteins Cell Cycle Proteins Channel Proteins Exosome GDP/GTP Binding Proteins Growth Factors and Hormones Homeodomain Proteins Immunohistochemical Kinases and Phosphatases Signaling

     

    Membrane Receptors Neurobiology Signaling Intermediates Steroid Receptors Structural Proteins Synthesis and Degradation Transcription Regulators Transport and Trafficking Tumor Suppressors/Apoptosis
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