Anti-Human MSH6 (ABT-MSH6) Mouse Monoclonal Antibody

Assay Biotechnology Inc Antibodies and ELISA Kits have been rigorously validated for laboratory grade quality results. High specificity paired with high affinity for targets of interest give researchers an advantage with our products

Catalog No: V0394

Reactivity:Human

Application:IHC,WB,IF

Modification:Unmodified/ Total

Source:Monoclonal Mouse

Storage and Stability:Stable at -20°C for at least 1 year.

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Datasheet

SDS

Immunohistochemical

Sample Sized mAbs 5477

Pathology Grade Abs

Anti-Human MSH6 (ABT-MSH6) Mouse Monoclonal Antibody

Human colon adenocarcinoma tissue with loss of MSH6 expression was stained with Anti-MSH6 (ABT-MSH6) Antibody

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Lead Time

Antibodies 1-2 business day, ELISA kits 2-3 business day lead time

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408-747-0185

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408-747-0145

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Product Details

Product Name

Anti-Human MSH6 (ABT-MSH6) Mouse Monoclonal Antibody

Description

This gene encodes a member of the DNA mismatch repair MutS family. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein heterodimerizes with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene may be associated with hereditary nonpolyposis colon cancer, colorectal cancer, and endometrial cancer. Transcripts variants encoding different isoforms have been described. [provided by RefSeq, Jul 2013],

Catalog No

V0394

Reactivity

Human

Application

IHC,WB,IF

Modification

Unmodified/ Total

Source

Monoclonal Mouse

Storage and Stability

Stable at -20°C for at least 1 year.

Other Name

DNA mismatch repair protein Msh6, G/T mismatch binding protein, G/T mismatch-binding protein, GTBP, GTMBP, hMSH6, HNPCC 5, HNPCC5, HSAP, MSH 6, MSH6, MSH6_HUMAN, mutS (E. coli) homolog 6, MutS alpha 160 kDa subunit, MutS homolog 6 (E. coli), mutS homolog 6, MutS-alpha 160 kDa subunit, p160, Sperm associated protein

Gene Name

MSH6

UniProtKB

P52701

Clone ID

ABT-MSH6

Isotype

IgG1, Kappa

Localization

Nuclear

Positive Tissue Control

Colon adenocarcinoma with normal MSH6 expression /Colon/ Tonsil

Specificity

The antibody can specifically recognize human MSH6 protein. In western blotting of HEK293 cell lysate, the antibody can label a 180 kDa band corresponding to MSH6, while there is no band detected in MSH6 knock out HEK293 cell lysate.

Formulation

PBS, pH7.2, 0.03% Proclin 300, 50% glycerol