Anti-Human Androgen Receptor (ABT101) Mouse Monoclonal Antibody

Assay Biotechnology Inc Antibodies and ELISA Kits have been rigorously validated for laboratory grade quality results. High specificity paired with high affinity for targets of interest give researchers an advantage with our products

Catalog No: V0179

Reactivity:Human

Application:IHC,WB

Modification:Unmodified/ Total

Source:Monoclonal Mouse

Storage and Stability:Stable at -20°C for at least 1 year.

Size:

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Datasheet

SDS

Immunohistochemical

Sample Sized mAbs 5477

Pathology Grade Abs

Anti-Human Androgen Receptor (ABT101) Mouse Monoclonal Antibody

Human prostate tissue was stained with anti-AR(ABT101) antibody.

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Lead Time

Antibodies 1-2 business day, ELISA kits 2-3 business day lead time

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408-747-0185

Fax

408-747-0145

order@assaybiotech.com

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Product Details

Product Name

Anti-Human Androgen Receptor (ABT101) Mouse Monoclonal Antibody

Description

The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract from the normal 9-34 repeats to the pathogenic 38-62 repeats causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoform

Catalog No

V0179

Reactivity

Human

Application

IHC,WB

Modification

Unmodified/ Total

Source

Monoclonal Mouse

Storage and Stability

Stable at -20°C for at least 1 year.

Other Name

AIS, Androgen receptor, AR, AR8, DHTR, Dihydro testosterone receptor, Dihydrotestosterone receptor (DHTR), HUMARA, HYSP1, KD, NR3C4, Nuclear receptor subfamily 3 group C member 4 (NR3C4), Nuclear receptor subfamily 3 group C member 4, SBMA, SMAX1, Spinal and bulbar muscular atrophy (SBMA), Spinal and bulbar muscular atrophy, Testicular Feminization (TFM), TFM

Gene Name

UniProtKB

P10275

Clone ID

ABT101

Isotype

IgG2b, kappa

Localization

Nuclear

Positive Tissue Control

Prostate

Specificity