Order your 5 sample sized mAbs for 77$ Order your Buy 1 get 1 on select products. Code: B1G1
Sign In/Register 0

We use cookies, check our Privacy Policies.

Anti-Human CA-125 (ABT-MUC16) Mouse Monoclonal Antibody
Anti-Human CA-125 (ABT-MUC16) Mouse Monoclonal Antibody

Assay Biotechnology Inc Antibodies and ELISA Kits have been rigorously validated for laboratory grade quality results. High specificity paired with high affinity for targets of interest give researchers an advantage with our products

Catalog No: V0010
Reactivity:Human
Application:IHC
Modification:Unmodified/ Total
Source:Monoclonal Mouse
Storage and Stability:Stable at -20°C for at least 1 year.

$Sample Size
Product Details
Product Name
Anti-Human CA-125 (ABT-MUC16) Mouse Monoclonal Antibody
Description
domain:Composed of three domains, a Ser-, Thr-rich N-terminal domain, a repeated domain containing more than 60 partially conserved tandem repeats of 156 amino acids each (AAs 12061-21862) and a C-terminal transmembrane contain domain with a short cytoplasmic tail.,function:Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces.,induction:Up-regulated in ovarian cancer cells.,miscellaneous:Antigen that is the basis for a widely used serum assay for the monitoring of patients with ovarian epithelial cancer. Due to lack of sensitivity for stage I disease and lack of specificity, it is of little value in the detection of early ovarian cancer. Due to its similarly elevated levels in some nonmalignant conditions, it is not specific enough to be used for population screening.,polymorphism:The number of repeats is highly polymorphic.,PTM:Heavily N-glycosylated; expresses primarily high mannose and complex bisecting type N-linked glycans.,PTM:Heavily O-glycosylated; expresses both type 1 and type 2 core glycans.,PTM:May be phosphorylated. Phosphorylation of the intracellular C-terminal domain may induce proteolytic cleavage and the liberation of the extracellular domain into the extracellular space.,PTM:May contain numerous disulfide bridges. Association of several molecules of the secreted form may occur through interchain disulfide bridges providing an extraordinarily large gel-like matrix in the extracellular space or in the lumen of secretory ducts.,similarity:Contains 14 LRR (leucine-rich) repeats.,similarity:Contains 2 ANK repeats.,similarity:Contains 56 SEA domains.,subcellular location:May be liberated into the extracellular space following the phosphorylation of the intracellular C-terminus which induces the proteolytic cleavage and liberation of the extracellular domain.,subunit:Binds to MSLN. Binding to MSLN mediates heterotypic cell adhesion. This may contribute to the metastasis of ovarian cancer to the peritoneum by initiating cell attachment to the mesothelial epithelium via binding to MSLN.,tissue specificity:Expressed in corneal and conjunctival epithelia (at protein level). Overexpressed in ovarian carcinomas and ovarian low malignant potential (LMP) tumors as compared to the expression in normal ovarian tissue and ovarian adenomas.,
Catalog No
V0010
Reactivity
Human
Application
IHC
Modification
Unmodified/ Total
Source
Monoclonal Mouse
Storage and Stability
Stable at -20°C for at least 1 year.
Other Name
CA 125, CA-125, CA125, CA125 ovarian cancer antigen, Cancer antigen 125, FLJ14303, MUC 16, MUC-16, MUC16, MUC16_HUMAN, Mucin 16, Mucin 16 cell surface associated, Mucin-16, Mucin16, Ovarian cancer related tumor marker CA125, Ovarian cancer-related tumor marker CA125, Ovarian carcinoma antigen CA125
Gene Name
MUC16
UniProtKB
Q8WXI7
Clone ID
ABT-MUC16
Isotype
IgG1, Kappa
Localization
Membranous, Cytoplasmic
Positive Tissue Control
Fallopian tube
Specificity
The antibody can specifically recognize human CA-125 protein.
Formulation
PBS, pH7.2, 0.03% Proclin 300, 50% glycerol
Related Products