ATP binding cassette subfamily G member 2 (Junior blood group)(ABCG2) Homo sapiens. The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue. Multiple transcript variants encoding different isoforms have been found for this gene.
Catalog No
N0007
Reactivity
Human,Mouse,Monkey
Applications
WB,IHC-p,IF/ICC,FCM,ELISA
Modification
Unmodfied/ Total
Source
Monoclonal Mouse
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/200 - 1/1000. Immunofluorescence: 1/200 - 1/1000. Flow cytometry: 1/200 - 1/400. ELISA: 1/10000. Not yet tested in other applications.
Purification
Affinity purification
Concentration
Storage and Stability
-20°C/1 year
Other Name
ABCG2; ABCP; BCRP; BCRP1; MXR; ATP-binding cassette sub-family G member 2; Breast cancer resistance protein; CDw338; Mitoxantrone resistance-associated protein; Placenta-specific ATP-binding cassette transporter; CD antigen CD338
Molecular Weight (Da)
Gene Name
ABCG2
Protein Name
ATP-binding cassette sub-family G member 2
Human Gene ID
9429
Human Swiss Prot No.
Q9UNQ0
Immunogen
Purified recombinant fragment of human ABCG2 expressed in E. Coli.
Specificity
ABCG2 Monoclonal Antibody detects endogenous levels of ABCG2 protein.
Immunofluorescence analysis of Hela cells using ABCG2 Monoclonal Antibody (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.
Immunohistochemistry analysis of paraffin-embedded bladder cancer tissues (left) and skeletal muscle tissues (right) with DAB staining using ABCG2 Monoclonal Antibody.
