Description
ATM serine/threonine kinase(ATM)Homo sapiens. The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. [provided by RefSeq, Aug 2010],
Reactivity
Human
Applications
WB,ELISA
Modification
Unmodfied/ Total
Source
Monoclonal Mouse
Dilution
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Purification
Affinity purification
Concentration
Storage and Stability
-20°C/1 year
Other Name
ATM; Serine-protein kinase ATM; Ataxia telangiectasia mutated; A-T mutated
Molecular Weight (Da)
Gene Name
ATM
Protein Name
Serine-protein kinase ATM
Human Gene ID
472
Human Swiss Prot No.
Q13315
Immunogen
Purified recombinant fragment of human Atm expressed in E. Coli.
Specificity
Atm Monoclonal Antibody detects endogenous levels of Atm protein.
Formulation
Ascitic fluid containing 0.03% sodium azide,0.5% BSA, 50%glycerol.
