beclin 1(BECN1)Homo sapiens. This gene encodes a protein that regulates autophagy, a catabolic process of degradation induced by starvation. The encoded protein is a component of the phosphatidylinositol-3-kinase (PI3K) complex which mediates vesicle-trafficking processes. This protein is thought to play a role in multiple cellular processes, including tumorigenesis, neurodegeneration and apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015],
Catalog No
N0059
Reactivity
Human
Applications
WB,IHC-p,IF(paraffin section),FCM,ELISA
Modification
Unmodfied/ Total
Source
Monoclonal Mouse
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/200 - 1/1000. Flow cytometry: 1/200 - 1/400. ELISA: 1/10000. Not yet tested in other applications.
Purification
Affinity purification
Concentration
Storage and Stability
-20°C/1 year
Other Name
BECN1; GT197; Beclin-1; Coiled-coil myosin-like BCL2-interacting protein; Protein GT197
Molecular Weight (Da)
Gene Name
BECN1
Protein Name
Beclin-1
Human Gene ID
8678
Human Swiss Prot No.
Q14457
Immunogen
Purified recombinant fragment of human Beclin-1 expressed in E. Coli.
Specificity
Beclin-1 Monoclonal Antibody detects endogenous levels of Beclin-1 protein.
Immunohistochemistry analysis of paraffin-embedded breast cancer tissues (left) and liver cancer tissues (right) with DAB staining using Beclin-1 Monoclonal Antibody.
