prominin 1(PROM1)Homo sapiens. This gene encodes a pentaspan transmembrane glycoprotein. The protein localizes to membrane protrusions and is often expressed on adult stem cells, where it is thought to function in maintaining stem cell properties by suppressing differentiation. Mutations in this gene have been shown to result in retinitis pigmentosa and Stargardt disease. Expression of this gene is also associated with several types of cancer. This gene is expressed from at least five alternative promoters that are expressed in a tissue-dependent manner. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009],
Catalog No
N0101
Reactivity
Human
Applications
IHC-p,IF(paraffin section),FCM,ELISA
Modification
Unmodfied/ Total
Source
Monoclonal Mouse
Dilution
Immunohistochemistry: 1/200 - 1/1000. Flow cytometry: 1/200 - 1/400. ELISA: 1/10000. Not yet tested in other applications.
Purification
Affinity purification
Concentration
Storage and Stability
-20°C/1 year
Other Name
PROM1; Prominin-1; Antigen AC133; Prominin-like protein 1; CD antigen CD133
Molecular Weight (Da)
Gene Name
PROM1
Protein Name
Prominin-1
Human Gene ID
8842
Human Swiss Prot No.
O43490
Immunogen
Synthesized peptide of human CD133.
Specificity
CD133 Monoclonal Antibody detects endogenous levels of CD133 protein.
Immunohistochemistry analysis of paraffin-embedded human breast cancer tissues (left) and human esophageal cancer tissues (right) with DAB staining using CD133 Monoclonal Antibody.
