REL proto-oncogene, NF-kB subunit(REL) Homo sapiens. This gene encodes a protein that belongs to the Rel homology domain/immunoglobulin-like fold, plexin, transcription factor (RHD/IPT) family. Members of this family regulate genes involved in apoptosis, inflammation, the immune response, and oncogenic processes. This proto-oncogene plays a role in the survival and proliferation of B lymphocytes. Mutation or amplification of this gene is associated with B-cell lymphomas, including Hodgkin's lymphoma. Single nucleotide polymorphisms in this gene are associated with susceptibility to ulcerative colitis and rheumatoid arthritis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014],
Catalog No
N0163
Reactivity
Human,Mouse
Applications
WB,IHC-p,IF/ICC,ELISA
Modification
Unmodfied/ Total
Source
Monoclonal Mouse
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/200 - 1/1000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
Purification
Affinity purification
Concentration
Storage and Stability
-20°C/1 year
Other Name
REL; Proto-oncogene c-Rel
Molecular Weight (Da)
Gene Name
REL
Protein Name
Proto-oncogene c-Rel
Human Gene ID
5966
Human Swiss Prot No.
Q04864
Immunogen
Purified recombinant fragment of human c-Rel expressed in E. Coli.
Specificity
c-Rel Monoclonal Antibody detects endogenous levels of c-Rel protein.
Immunofluorescence analysis of U251 cells using c-Rel Monoclonal Antibody (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.
Immunohistochemistry analysis of paraffin-embedded endometrial cancer tissues (left) and liver cancer tissues (right) with DAB staining using c-Rel Monoclonal Antibody.
