CRK like proto-oncogene, adaptor protein(CRKL) Homo sapiens. This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.[provided by RefSeq, Jan 2009],
Catalog No
N0167
Reactivity
Human
Applications
WB,FCM,ELISA
Modification
Unmodfied/ Total
Source
Monoclonal Mouse
Dilution
Western Blot: 1/500 - 1/2000. Flow cytometry: 1/200 - 1/400. ELISA: 1/10000. Not yet tested in other applications.
Purification
Affinity purification
Concentration
Storage and Stability
-20°C/1 year
Other Name
CRKL; Crk-like protein
Molecular Weight (Da)
Gene Name
CRKL
Protein Name
Crk-like protein
Human Gene ID
1399
Human Swiss Prot No.
P46109
Immunogen
Purified recombinant fragment of human Crk-L expressed in E. Coli.
Specificity
Crk-L Monoclonal Antibody detects endogenous levels of Crk-L protein.
