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Primary Antibodies
Active Caspase-3 Monoclonal Antibody(5E1)
Active Caspase-3 Monoclonal Antibody(5E1)

Assay Biotechnology Inc Antibodies and ELISA Kits have been rigorously validated for laboratory grade quality results. High specificity paired with high affinity for targets of interest give researchers an advantage with our products

Catalog No: N1519
Reactivity:Human,Mouse,Rat,Chicken
Applications:IF/ICC,WB,IHC-p
Modification:Unmodfied/ Total
Source:Monoclonal Mouse
Storage and Stability:-20°C/1 year

$160
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Active Caspase-3 Monoclonal Antibody(5E1)

Western blot analysis of 1) Hela. 2) 3T3. 3) Rat Brain Tissue using Active Caspase-3 Monoclonal Antibody.

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Product Details
Product Name
Active Caspase-3 Monoclonal Antibody(5E1)
Description
caspase 3(CASP3)Homo sapiens. This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein. [provided by RefSeq, Jul 2008],
Catalog No
N1519
Reactivity
Human,Mouse,Rat,Chicken
Applications
IF/ICC,WB,IHC-p
Modification
Unmodfied/ Total
Source
Monoclonal Mouse
Dilution
IF: 1:50-200 WB: 1:500-1000 IHC: 1:100-200
Purification
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
Concentration
Storage and Stability
-20°C/1 year
Other Name
CASP3; CPP32; Caspase-3; CASP-3; Apopain; Cysteine protease CPP32; CPP-32; Protein Yama; SREBP cleavage activity 1; SCA-1
Molecular Weight (Da)
Gene Name
CASP3
Protein Name
Caspase3
Human Gene ID
836
Human Swiss Prot No.
P42574
Immunogen
Recombinant Protein of Active Caspase-3
Specificity
The antibody detects endogenous Active Caspase-3 protein.
Formulation
PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.
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Publications (12)
circEXOC6B interacting with RRAGB, an mTORC1 activator, inhibits the progression of colorectal cancer by antagonizing the HIF1A-RRAGB-mTORC1 positive feedback loop

Author: Li, Xiaomin, Wang, Jianjun, Lin, Weihao, Yuan, Qinzi, Lu, Yanxia, Wang, Haowei, Chen, Yujia, Chen, Lixia, Dai, Peiling, Long, Huaicheng, Li, Xuenong

Date of Publication : 2022-06-23

Protective effects of flavonoids from the leaves of Carya cathayensis Sarg. against H2O2‑induced oxidative damage and apoptosis in vitro

Author: Fang-Mei Zhou, Jing-Jing Huang, Xu-Jiao Hu, Jingwei Wang, Bing-Qi Zhu, Zhi-Shan Ding, Shigao Huang, Jing-Jing Fang

Date of Publication : 2021-10-13

Ganoderic Acids Prevent Renal Ischemia Reperfusion Injury by Inhibiting Inflammation and Apoptosis

Author: Guangying Shao, Jinzhao He, Jia Meng, Ang Ma, Xiaoqiang Geng, Shun Zhang, Zhiwei Qiu, Dongmei Lin, Min Li, Hong Zhou, Shuqian Lin, Baoxue Yang

Date of Publication : 2021-09-23

A preparation of Ginkgo biloba L. leaves extract inhibits the apoptosis of hippocampal neurons in post-stroke mice via regulating the expression of Bax/Bcl-2 and Caspase-3

Author: Zhixiong Li, Guangxu Xiao, Huanyi Wang, Shuang He, Yan Zhu

Date of Publication : 2021-07-31

Effects of medicine food Fructus Gardeniae on liver and kidney functions after oral administration to rats for 12 weeks

Author: Chunnan Li, Xu Gao, Xiaochen Gao, Jingwei Lv, Xuefeng Bian, Jinpeng Lv, Jiaming Sun, Guangming Luo, Hui Zhang

Date of Publication : 2021-06-04

Danggui-Shaoyao-San (DSS) Ameliorates Cerebral Ischemia-Reperfusion Injury via Activating SIRT1 Signaling and Inhibiting NADPH Oxidases

Author: Luo Yunxia, Chen Hansen, Tsoi Bun, Wang Qi, Shen Jiangang

Date of Publication : 2021-04-15

Apoptosis inhibition is involved in improvement of sevoflurane‑induced cognitive impairment following normobaric hyperoxia preconditioning in aged rats

Author: Ying Wang, Chun-Ping Yin, Yan-Lei Tai, Zi-Jun Zhao, Zhi-Yong Hou, Qiu-Jun Wang

Date of Publication : 2021-01-11

Influence of oxidation on heat shock protein 27 translocation, caspase-3 and calpain activities and myofibrils degradation in postmortem beef muscles

Author: Zhenjiang Ding, Qichao Wei, Chunjiang Zhang, Hong Zhang, Feng Huang

Date of Publication : 2020-08-29

The role of SIRT1 in BMP2-induced chondrogenic differentiation and cartilage maintenance under oxidative stress.

Author: Yang Lu, Li Zhou, Lijun Wang, Shan He, Honglei Ren, Nian Zhou, Zhenming Hu

Date of Publication : 2020-05-01

A Novel Resveratrol-Arsenic Trioxide Combination Treatment Synergistically Induces Apoptosis of Adriamycin-Selected Drug-Resistant Leukemia K562 Cells

Author: Jing Chen, Baoying Tian, Cunmin Zhou, Jingjing Sun, Li Lin, Shucheng Jin, Quanrui Liu, Siyu Fu, Lian Liu, Hang Liu, Zhewen Zhang, Caili Li, Hulai Wei

Date of Publication : 2019-08-29

Eugenol protects the transplanted heart against ischemia/reperfusion injury in rats by inhibiting the inflammatory response and apoptosis

Author: Wei Fen, Longyu Jin, Qianyi Xie, Lihua Huang, Zhibin Jiang, Ying Ji, Chunyun Li, Linfei Yang, Dianjun Wang

Date of Publication : 2018-08-13

Baicalin Attenuates Blood-Brain Barrier Disruption and Hemorrhagic Transformation and Improves Neurological Outcome in Ischemic Stroke Rats with Delayed t-PA Treatment: Involvement of ONOO − -MMP-9 Pathway

Author: Chen, Hansen, Guan, Binghe, Chen, Xi, Chen, Xingmiao, Li, Caiming, Qiu, Jinhua, Yang, Dan, Liu, Ke Jian, Qi, Suhua, Shen, Jiangang

Date of Publication : 2017-12-23

Primary Antibodies

    • ELISA Kits

    • Research Areas

    Cell Adhesion Proteins Cell Cycle Proteins Channel Proteins Exosome GDP/GTP Binding Proteins Growth Factors and Hormones Homeodomain Proteins Immunohistochemical Kinases and Phosphatases Signaling

     

    Membrane Receptors Neurobiology Signaling Intermediates Steroid Receptors Structural Proteins Synthesis and Degradation Transcription Regulators Transport and Trafficking Tumor Suppressors/Apoptosis
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