estrogen receptor 2(ESR2)Homo sapiens. This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized. [provided by RefSeq, Jul 2008],
Catalog No
N1747
Reactivity
Human
Applications
IHC-p,IF(paraffin section),WB
Modification
Unmodfied/ Total
Source
Monoclonal Mouse
Dilution
IHC-p 1:100-300，WB 1:500-2000
Purification
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Concentration
1 mg/ml
Storage and Stability
-20°C/1 year
Other Name
Estrogen receptor beta (ER-beta) (Nuclear receptor subfamily 3 group A member 2)
Molecular Weight (Da)
Gene Name
ESR2 ESTRB NR3A2
Protein Name
Estrogen Receptor β
Human Gene ID
2100
Human Swiss Prot No.
Q92731
Immunogen
Synthesized peptide derived from human Estrogen Receptor β
Specificity
This antibody detects endogenous levels of human Estrogen Receptor β
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
