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Primary Antibodies
Smad2/3 Antibody
Smad2/3 Antibody

Assay Biotechnology Inc Antibodies and ELISA Kits have been rigorously validated for laboratory grade quality results. High specificity paired with high affinity for targets of interest give researchers an advantage with our products

Catalog No: B1001
Reactivity:Human,Mouse,Rat,Monkey,Pig
Applications:WB,IHC,IF,ELISA
Modification:Unmodified/Total
Source:Polyclonal,Rabbit,IgG
Storage and Stability:Store at -20°C/1 year

$205
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Smad2/3 Antibody

Immunohistochemical analysis of paraffin-embedded Human-stomach tissue. 1,Smad2/3 Polyclonal Antibody was diluted at 1:200(4°C,overnight). 2, Sodium citrate pH 6.0 was used for antibody retrieval(>98°C,20min). 3,Secondary antibody was diluted at 1:200(room tempeRature, 30min). Negative control was used by secondary antibody only.

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Product Details
Product Name
Smad2/3 Antibody
Description
The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation
Catalog No
B1001
Reactivity
Human, Mouse, Rat, Monkey, Pig
Source
Polyclonal, Rabbit,IgG
Modification
Unmodified/Total
Applications
WB, IHC, IF, ELISA
Dilution
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Storage and Stability
Store at -20°C/1 year
Other Name
SMAD2; MADH2; MADR2; Mothers against decapentaplegic homolog 2; MAD homolog 2; Mothers against DPP homolog 2; JV18-1; Mad-related protein 2; hMAD-2; SMAD family member 2; SMAD 2; Smad2; hSMAD2; SMAD3; MADH3; Mothers against decapentaplegic
Molecular Weight (Da or kDa)
Gene Name
SMAD2/SMAD3
Protein Name
Mothers against decapentaplegic homolog 2/3
Human Gene ID
4087/4088
Human Swiss Prot No.
Q15796 / P84022
Immunogen
The antiserum was produced against synthesized peptide derived from human Smad2/3. AA range:1-50
Specificity
Smad2/3 Polyclonal Antibody detects endogenous levels of Smad2/3 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Publications (4)
Tanshinone IIA mediates SMAD7-YAP interaction to inhibit liver cancer growth by inactivating the transforming growth factor beta signaling pathway. Aging-US Aging-Us. 2019 Nov 15; 11(21): 9719–9737 WB Human 1:2000 Bel-7404 cell, SMMC-7721 cell

Author: Available in link provided

Date of Publication : Available in link provided

Inhibin B suppresses anoikis resistance and migration through the transforming growth factor‐β signaling pathway in nasopharyngeal carcinoma. CANCER SCIENCE Cancer Sci. 2018 Nov;109(11):3416-3427 WB Human HNE1 cell， 5-8F cell

Author: Available in link provided

Date of Publication : Available in link provided

Follistatin-like 1 attenuates differentiation and survival of erythroid cells through Smad2/3 signaling. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2015 Sep 10 WB Human K562 cell

Author: Available in link provided

Date of Publication : Available in link provided

Hypoxia-induced TREM1 promotes mesenchymal-like states of glioma stem cells via alternatively activating tumor-associated macrophages CANCER LETTERS Minhai Dong WB Human 1:1000 glioma stem cells (GSCs)

Author: Available in link provided

Date of Publication : Available in link provided

Primary Antibodies

    • ELISA Kits

    • Research Areas

    Cell Adhesion Proteins Cell Cycle Proteins Channel Proteins Exosome GDP/GTP Binding Proteins Growth Factors and Hormones Homeodomain Proteins Immunohistochemical Kinases and Phosphatases Signaling

     

    Membrane Receptors Neurobiology Signaling Intermediates Steroid Receptors Structural Proteins Synthesis and Degradation Transcription Regulators Transport and Trafficking Tumor Suppressors/Apoptosis
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