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Primary Antibodies
CDK5R1 (AB3045) Rabbit mAb
CDK5R1 (AB3045) Rabbit mAb

Assay Biotechnology Inc Antibodies and ELISA Kits have been rigorously validated for laboratory grade quality results. High specificity paired with high affinity for targets of interest give researchers an advantage with our products

Catalog No: M2588
Species Reactivity:Human,Mouse,Rat
Application:WB,IF/ICC,ELISA
Host:Rabbit
Clonality:Monoclonal
Storage and Stability:Store at-20℃. Avoid freeze / thaw cycles.

$150
# Datasheet #
# SDS #
Recombinant Antibody
20 ul Size Available
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CDK5R1 (AB3045) Rabbit mAb

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Product Details
Product Name
CDK5R1 (AB3045) Rabbit mAb
Description
The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5) ; the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease.
Catalog No
M2588
Species Reactivity
Human, Mouse, Rat
Clonality
Monoclonal
Host
Rabbit
Modifcation
Unmodified
Clone
AB3045
Isotype
IgG
Application
WB, IF/ICC, ELISA
Application Dilutions
WB, 1:2000-1:8000 | IF/ICC, 1:200-1:800 | ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 195 - 295 of human CDK5R1.
Specificity
This antibody detects endogenous levels of CDK5R1 protein.
Formulation
The antibody is provided in liquid form in phosphate - buffered saline with 50% glycerol, 0.05% BSA, and 0.05% proclin300.
Purification
The antibody was purified by protein A affinity chromatography.
Storage and Stability
Store at-20℃. Avoid freeze / thaw cycles.
Gene Name
CDK5R1
Gene ID
8851
Human swiss
Q15078
Protein Name
CDK5R1
Synonyms
p23; p25; p35; CDK5R; NCK5A; CDK5P35; p35nck5a; CDK5R1
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Primary Antibodies

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