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Siglec-8 (AX4423) Rabbit mAb
Siglec-8 (AX4423) Rabbit mAb

Assay Biotechnology Inc Antibodies and ELISA Kits have been rigorously validated for laboratory grade quality results. High specificity paired with high affinity for targets of interest give researchers an advantage with our products

Catalog No: M2423
Reactivity:Human,Mouse,Rat
Applications:WB,FC,ELISA
Modifcation:Unmodified
Source:Rabbit
Storage and Stability:Store at -20℃/ 1 year. Avoid freeze / thaw cycles.

$150
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Recombinant Antibody
20ul Size Available
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Siglec-8 (AX4423) Rabbit mAb

Flow cytometry: 1X10^6 Jurkat cells (negative control,left) and THP-1 cells (right) were surface-stained with CD141/Thrombomodulin Rabbit mAb (M2424,2.5 μg/mL,orange line) or ABflo® 647 Rabbit IgG isotype control (M2770,5 μl/Test,blue line), followed by Alexa Fluor® 647 conjugated goat anti-rabbit pAb staining. Non-fluorescently stained cells were used as blank control (red line).

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Product Details
Product Name
Siglec-8 (AX4423) Rabbit mAb
Description
Sialic acid-binding immunoglobulin (Ig)-like lectins, or SIGLECs (e.g., CD33 (MIM 159590)), are a family of type 1 transmembrane proteins each having a unique expression pattern, mostly in hemopoietic cells. SIGLEC8 is a member of the CD33-like subgroup of SIGLECs, which are localized to 19q13.3-q13.4 and have 2 conserved cytoplasmic tyrosine-based motifs: an immunoreceptor tyrosine-based inhibitory motif, or ITIM (see MIM 604964), and a motif homologous to one identified in signaling lymphocyte activation molecule (SLAM; MIM 603492) that mediates an association with SLAM-associated protein (SAP; MIM 300490) (summarized by Foussias et al., 2000 [PubMed 11095983]).
Catalog No
M2423
Reactivity
Human, Mouse, Rat
Applications
WB, FC, ELISA
Application Dilutions
WB,1:1000 - 1:5000 | FC,1:50 - 1:100 | ELISA,Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Modifcation
Unmodified
Source
Rabbit
Isotype
IgG
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 17-363 of human Siglec-8 (NP_055257.2).
Calculated MW (kDa)
54kDa
Observed MW (kDa)Gene Name
60kDaSIGLEC8
Other Name
SAF2; SIGLEC-8; SIGLEC8L; SIGLEC8; Siglec-8
Gene ID
27181
Human Swiss Prot
Q9NYZ4
Formulation
PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Storage and Stability
Store at -20℃/ 1 year. Avoid freeze / thaw cycles.
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Primary Antibodies

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