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Phospho-Smad2-S245/S250/S255
Phospho-Smad2-S245/S250/S255

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Catalog No: M2159
Reactivity:Human
Applications:WB,ELISA
Modifcation:Phospho S245/S250/S255
Source:Rabbit
Storage and Stability:Store at -20℃/ 1 year. Avoid freeze / thaw cycles.

$150
Product Details
Product Name
Phospho-Smad2-S245/S250/S255
Description
The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene.
Catalog No
M2159
Reactivity
Human
Applications
WB, ELISA
Application Dilutions
WB,1:1000 - 1:5000 | ELISA,Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Modifcation
Phospho S245/S250/S255
Source
Rabbit
Isotype
IgG
Immunogen
A synthetic phosphorylated peptide around S245 & S250 & S255 of human Smad2(Q15796)
Calculated MW (kDa)
52kDa
Observed MW (kDa)Gene Name
60kDaSMAD2
Other Name
JV18; LDS6; CHTD8; MADH2; MADR2; JV18-1; hMAD-2; hSMAD2; Phospho-Smad2-S245/S250/S255
Gene ID
4087
Human Swiss Prot
Q15796
Formulation
PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Storage and Stability
Store at -20℃/ 1 year. Avoid freeze / thaw cycles.
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