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α-Actinin-4 (AX3469) Rabbit mAb
α-Actinin-4 (AX3469) Rabbit mAb

Assay Biotechnology Inc Antibodies and ELISA Kits have been rigorously validated for laboratory grade quality results. High specificity paired with high affinity for targets of interest give researchers an advantage with our products

Catalog No: M1469
Reactivity:Human,Mouse,Rat
Applications:WB,IF/ICC,IP,ELISA
Modifcation:Unmodified
Source:Rabbit
Storage and Stability:Store at -20℃/ 1 year. Avoid freeze / thaw cycles.

$150
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Recombinant Antibody
20ul Size Available
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α-Actinin-4 (AX3469) Rabbit mAb

Confocal imaging of U-2 OS cells using α-Actinin-4 Rabbit mAb (M1469, dilution 1:100) followed by a further incubation with Cy3 Goat Anti-Rabbit IgG (H+L) (SA1138, dilution 1:500) (Red). The cells were counterstained with α-Tubulin Mouse mAb (W0051, dilution 1:400) followed by incubation with ABflo® 488-conjugated Goat Anti-Mouse IgG (H+L) Ab (SM1393, dilution 1:500) (Green). DAPI was used for nuclear staining (Blue). Objective: 100x.

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Product Details
Product Name
α-Actinin-4 (AX3469) Rabbit mAb
Description
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis.
Catalog No
M1469
Reactivity
Human, Mouse, Rat
Applications
WB, IF/ICC, IP, ELISA
Application Dilutions
WB,1:1000 - 1:4000 | IF/ICC,1:50 - 1:200 | IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells | ELISA,Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Modifcation
Unmodified
Source
Rabbit
Isotype
IgG
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human α-Actinin-4 (O43707).
Calculated MW (kDa)
105kDa
Observed MW (kDa)Gene Name
100kDaACTN4
Other Name
FSGS; FSGS1; ACTININ-4; α-Actinin-4
Gene ID
81
Human Swiss Prot
O43707
Formulation
PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Storage and Stability
Store at -20℃/ 1 year. Avoid freeze / thaw cycles.
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Primary Antibodies

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