SHC1 (Phospho Tyr349+Tyr350) Rabbit pAb

Assay Biotechnology Inc Antibodies and ELISA Kits have been rigorously validated for laboratory grade quality results. High specificity paired with high affinity for targets of interest give researchers an advantage with our products

Catalog No: C51128

Reactivity:Human,Mouse,Rat

Applications:IHC,WB

Modification:Phospho Specific

Source:Rabbit,polyclonal

Storage and Stability:Store at -20°C/1 year

Size:

Price/Quantity $300

Quantity:

Datasheet

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SHC1 (Phospho Tyr349+Tyr350) Rabbit pAb

Western Blot analysis of 1 MCF-7 cell 2 Serum-free treated ,using primary antibody at 1:1000 dilution. Secondary antibody(catalog

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Lead Time

Antibodies 1-2 business day, ELISA kits 2-3 business day lead time

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Product Details

Product Name

SHC1 (Phospho Tyr349+Tyr350) Rabbit pAb

Description

SHC adaptor protein 1(SHC1) Homo sapiens This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011],

Catalog No

C51128

Reactivity

Human, Mouse, Rat

Source

Rabbit,polyclonal

Modification

Phospho Specific

Applications

IHC, WB

Dilution

WB 1:500-2000 IHC 1:50-200

Purification

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration

1 mg/ml

Storage and Stability

Store at -20°C/1 year

Other Name

SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)

Molecular Weight (Da or kDa)

Gene Name

SHC1 SHC SHCA

Protein Name

SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)

Human Gene ID

6464

Human Swiss Prot No.

P29353

Immunogen

Synthesized peptide derived from human SHC1 (Phospho Tyr349+Tyr350)

Specificity

This antibody detects endogenous levels of SHC1 (Phospho Tyr349+Tyr350) Rabbit pAb at Human, Mouse,Rat

Formulation

Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.