Caspase 8 (Phospho Tyr448) Rabbit pAb

Assay Biotechnology Inc Antibodies and ELISA Kits have been rigorously validated for laboratory grade quality results. High specificity paired with high affinity for targets of interest give researchers an advantage with our products

Catalog No: C51102

Reactivity:Human,Mouse

Applications:IHC,WB

Modification:Phospho Specific

Source:Rabbit,polyclonal

Storage and Stability:Store at -20°C/1 year

Size:

Price/Quantity $300

Quantity:

Datasheet

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Caspase 8 (Phospho Tyr448) Rabbit pAb

Western Blot analysis of 1 Raji cell, 2 Serum-free treated ,using primary antibody at 1:1000 dilution. Secondary antibody(catalog

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Lead Time

Antibodies 1-2 business day, ELISA kits 2-3 business day lead time

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408-747-0145

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Product Details

Product Name

Caspase 8 (Phospho Tyr448) Rabbit pAb

Description

caspase 8(CASP8) Homo sapiens This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alt

Catalog No

C51102

Reactivity

Human, Mouse

Source

Rabbit,polyclonal

Modification

Phospho Specific

Applications

IHC, WB

Dilution

WB 1:500-2000 IHC 1:50-200

Purification

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration

1 mg/ml

Storage and Stability

Store at -20°C/1 year

Other Name

Caspase-8 (CASP-8) (EC 3.4.22.61) (Apoptotic cysteine protease) (Apoptotic protease Mch-5) (CAP4) (FADD-homologous ICE/ced-3-like protease) (FADD-like ICE) (FLICE) (ICE-like apoptotic protease 5) (MORT1-associated ced-3 homolog) (MACH) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10]

Molecular Weight (Da or kDa)

Gene Name

CASP8 MCH5

Protein Name

Human Gene ID

841

Human Swiss Prot No.

Q14790

Immunogen

Synthesized peptide derived from human Caspase 8 (Phospho Tyr448)

Specificity

This antibody detects endogenous levels of Caspase 8 (Phospho Tyr448) Rabbit pAb at Human, Mouse