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Primary Antibodies
PSEN1 (Phospho Ser353) Rabbit pAb
PSEN1 (Phospho Ser353) Rabbit pAb

Assay Biotechnology Inc Antibodies and ELISA Kits have been rigorously validated for laboratory grade quality results. High specificity paired with high affinity for targets of interest give researchers an advantage with our products

Catalog No: C51094
Reactivity:Human,Mouse,Rat
Applications:IHC,WB
Modification:Phospho Specific
Source:Rabbit,polyclonal
Storage and Stability:Store at -20°C/1 year

$300
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PSEN1 (Phospho Ser353) Rabbit pAb

Western Blot analysis of mouse kidney tissue using primary antibody at 1:1000 dilution 4°C, overnight. Secondary antibody(catalog

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Product Details
Product Name
PSEN1 (Phospho Ser353) Rabbit pAb
Description
presenilin 1(PSEN1) Homo sapiens Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq, Aug 2008],
Catalog No
C51094
Reactivity
Human, Mouse, Rat
Source
Rabbit,polyclonal
Modification
Phospho Specific
Applications
IHC, WB
Dilution
WB 1:500-2000 IHC 1:50-200
Purification
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Concentration
1 mg/ml
Storage and Stability
Store at -20°C/1 year
Other Name
Presenilin-1 (PS-1) (EC 3.4.23.-) (Protein S182) [Cleaved into: Presenilin-1 NTF subunit; Presenilin-1 CTF subunit; Presenilin-1 CTF12 (PS1-CTF12)]
Molecular Weight (Da or kDa)
Gene Name
PSEN1 AD3 PS1 PSNL1
Protein Name
Presenilin-1 (PS-1) (EC 3.4.23.-) (Protein S182) [Cleaved into: Presenilin-1 NTF subunitPresenilin-1 CTF subunitPresenilin-1 CTF12 (PS1-CTF12)]
Human Gene ID
5663
Human Swiss Prot No.
P49768
Immunogen
Synthesized peptide derived from human PSEN1 (Phospho Ser353)
Specificity
This antibody detects endogenous levels of PSEN1 (Phospho Ser353) Rabbit pAb at Human, Mouse,Rat
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
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Primary Antibodies

    • ELISA Kits

    • Research Areas

    Cell Adhesion Proteins Cell Cycle Proteins Channel Proteins Exosome GDP/GTP Binding Proteins Growth Factors and Hormones Homeodomain Proteins Immunohistochemical Kinases and Phosphatases Signaling

     

    Membrane Receptors Neurobiology Signaling Intermediates Steroid Receptors Structural Proteins Synthesis and Degradation Transcription Regulators Transport and Trafficking Tumor Suppressors/Apoptosis
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