CD247 molecule(CD247) Homo sapiens. The protein encoded by this gene is T-cell receptor zeta, which together with T-cell receptor alpha/beta and gamma/delta heterodimers, and with CD3-gamma, -delta and -epsilon, forms the T-cell receptor-CD3 complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
Catalog No
N0116
Reactivity
Human
Applications
IF/ICC,ELISA
Modification
Unmodfied/ Total
Source
Monoclonal Mouse
Dilution
Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
Purification
Affinity purification
Concentration
1 mg/ml
Storage and Stability
-20°C/1 year
Other Name
CD247; CD3Z; T3Z; TCRZ; T-cell surface glycoprotein CD3 zeta chain; T-cell receptor T3 zeta chain; CD antigen CD247
Molecular Weight (Da)
Gene Name
CD247
Protein Name
T-cell surface glycoprotein CD3 zeta chain
Human Gene ID
919
Human Swiss Prot No.
P20963
Immunogen
Purified recombinant fragment of human CD3 expressed in E. Coli.
Specificity
CD3 Monoclonal Antibody-FITC labled detects endogenous levels of CD3 protein.
Formulation
Purified antibody in PBS containing 0.03% sodium azide.
