keratin 19(KRT19)Homo sapiens. The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells. It is specifically expressed in the periderm, the transiently superficial layer that envelopes the developing epidermis. The type I cytokeratins are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2008],
Catalog No
N0184
Reactivity
Human
Applications
WB,IHC-p,IF(paraffin section),ELISA
Modification
Unmodfied/ Total
Source
Monoclonal Mouse
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
Purification
Affinity purification
Concentration
Storage and Stability
-20°C/1 year
Other Name
KRT19; Keratin; type I cytoskeletal 19; Cytokeratin-19; CK-19; Keratin-19; K19
Molecular Weight (Da)
Gene Name
KRT19
Protein Name
Keratin type I cytoskeletal 19
Human Gene ID
3880
Human Swiss Prot No.
P08727
Immunogen
Purified recombinant fragment of human Cytokeratin 19 expressed in E. Coli.
Immunohistochemistry analysis of paraffin-embedded rectum cancer tissues (left) and lung cancer tissues (right) with DAB staining using Cytokeratin 19 Monoclonal Antibody.
Western Blot analysis using Cytokeratin 19 Monoclonal Antibody against T47D (1). MCF-7 (2). SKBR-3 (3). HepG2 (4). Caco-2 (5) and SW620 (6) cell lysate.
