desmin(DES) Homo sapiens. This gene encodes a muscle-specific class III intermediate filament. Homopolymers of this protein form a stable intracytoplasmic filamentous network connecting myofibrils to each other and to the plasma membrane. Mutations in this gene are associated with desmin-related myopathy, a familial cardiac and skeletal myopathy (CSM), and with distal myopathies. [provided by RefSeq, Jul 2008],
Catalog No
N0196
Reactivity
Human
Applications
WB,IHC-p,IF(paraffin section),ELISA
Modification
Unmodfied/ Total
Source
Monoclonal Mouse
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
Purification
Affinity purification
Concentration
1 mg/ml
Storage and Stability
-20°C/1 year
Other Name
DES; Desmin
Molecular Weight (Da)
Gene Name
DES
Protein Name
Desmin
Human Gene ID
1674
Human Swiss Prot No.
P17661
Immunogen
Purified recombinant fragment of Desmin expressed in E. Coli.
Specificity
Desmin Monoclonal Antibody detects endogenous levels of Desmin protein.
Formulation
Purified antibody in PBS containing 0.03% sodium azide.
Immunohistochemistry analysis of paraffin-embedded human smooth musde sarcoma. showing cytoplasmic localization with DAB staining using Desmin Monoclonal Antibody.
Western Blot analysis using Desmin Monoclonal Antibody against HEK293T cells transfected with the pCMV6-ENTRY control (1) and pCMV6-ENTRY Desmin cDNA (2).
