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Primary Antibodies
PTEN mouse Monoclonal Antibody(2C10)
PTEN mouse Monoclonal Antibody(2C10)

Assay Biotechnology Inc Antibodies and ELISA Kits have been rigorously validated for laboratory grade quality results. High specificity paired with high affinity for targets of interest give researchers an advantage with our products

Catalog No: N1641
Reactivity:Human
Applications:IHC-p,IF(paraffin section)
Modification:Unmodfied/ Total
Source:Monoclonal Mouse
Storage and Stability:-20°C/1 year

$160
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Tumor Suppressors/Apoptosis
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PTEN mouse Monoclonal Antibody(2C10)

Immunohistochemical analysis of paraffin-embedded Human Colon Carcinoma Tissue using PTEN Mouse mAb diluted at 1:200.

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Product Details
Product Name
PTEN mouse Monoclonal Antibody(2C10)
Description
phosphatase and tensin homolog(PTEN) Homo sapiens. This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. The use of a non-canonical (CUG) upstream initiation site produces a longer isoform that initiates translation with a leucine, and is thought to be preferentially associated with the mitochondrial inner membrane. This longer isoform may help regulate ener
Catalog No
N1641
Reactivity
Human
Applications
IHC-p,IF(paraffin section)
Modification
Unmodfied/ Total
Source
Monoclonal Mouse
Dilution
IHC 1:100-200
Purification
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Concentration
1 mg/ml
Storage and Stability
-20°C/1 year
Other Name
PTEN
Molecular Weight (Da)
Gene Name
PTEN
Protein Name
PTEN
Human Gene ID
5728
Human Swiss Prot No.
P60484
Immunogen
Synthetic Peptide of PTEN at AA range of 320-400
Specificity
PTEN protein detects endogenous levels of PTEN
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Primary Antibodies

    • ELISA Kits

    • Research Areas

    Cell Adhesion Proteins Cell Cycle Proteins Channel Proteins Exosome GDP/GTP Binding Proteins Growth Factors and Hormones Homeodomain Proteins Immunohistochemical Kinases and Phosphatases Signaling

     

    Membrane Receptors Neurobiology Signaling Intermediates Steroid Receptors Structural Proteins Synthesis and Degradation Transcription Regulators Transport and Trafficking Tumor Suppressors/Apoptosis
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