protein kinase AMP-activated catalytic subunit alpha 1(PRKAA1) Homo sapiens. The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008],
Catalog No
N1660
Reactivity
Human,Rat,Mouse
Applications
WB,IHC-p,IF(paraffin section)
Modification
Unmodfied/ Total
Source
Monoclonal Mouse
Dilution
WB 1:1000-2000, IHC 1:100-200
Purification
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Concentration
1 mg/ml
Storage and Stability
-20°C/1 year
Other Name
PRKAA1
Molecular Weight (Da)
Gene Name
PRKAA1
Protein Name
PRKAA1
Human Gene ID
5562
Human Swiss Prot No.
Q13131
Immunogen
Recombinant Protein of AMPKα1 of PRKAA1
Specificity
AMPKα1 protein detects endogenous levels of PRKAA1
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
