thyroid peroxidase(TPO)Homo sapiens. This gene encodes a membrane-bound glycoprotein. The encoded protein acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Multiple transcript variants encoding distinct isoforms have been identified for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, May 2011],
Catalog No
N1738
Reactivity
Human
Applications
WB
Modification
Unmodfied/ Total
Source
Monoclonal Mouse
Dilution
WB 1:500-2000
Purification
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Concentration
1 mg/ml
Storage and Stability
-20°C/1 year
Other Name
Thyroid peroxidase (TPO) (EC 1.11.1.8)
Molecular Weight (Da)
Gene Name
TPO
Protein Name
Thyroid Peroxidase(TPO)
Human Gene ID
7173
Human Swiss Prot No.
P07202
Immunogen
Synthesized peptide derived from human Thyroid Peroxidase(TPO)
Specificity
This antibody detects endogenous levels of human Thyroid Peroxidase(TPO)
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
