Anti-Human PIK3CA H1047R (ABT454) Mouse Monoclonal Antibody

Assay Biotechnology Inc Antibodies and ELISA Kits have been rigorously validated for laboratory grade quality results. High specificity paired with high affinity for targets of interest give researchers an advantage with our products

Catalog No: V0439

Reactivity:Human

Application:IHC,WB

Modification:Unmodified/ Total

Source:Monoclonal Mouse

Storage and Stability:Stable at -20°C for at least 1 year.

Size:

Price/Quantity $95

Quantity:

Datasheet

SDS

Immunohistochemical

Anti-Human PIK3CA H1047R (ABT454) Mouse Monoclonal Antibody

Human gastric adenocarcinoma tissue was stained with Anti-PIK3CA H1047R (ABT454) Antibody

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Lead Time

Antibodies 1-2 business day, ELISA kits 2-3 business day lead time

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408-747-0185

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408-747-0145

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Product Details

Product Name

Anti-Human PIK3CA H1047R (ABT454) Mouse Monoclonal Antibody

Description

The PIK3CA gene is located at 3Q26.3 and encodes a 124 kDa protein. The protein is composed of 85 kDa regulatory subunit and 110 kDa catalytic subunit. The most common mutations of PIK3CA occur in exon 9 and exon 20. H1047R, one of the most common mutations occurs in exon 20. PIK3CA plays an important role in the PI3K/AKT/mTOR signaling pathway, which can be activated by this mutation, closely related to the occurrence of tumors and disease progression. In non-small cell lung cancer, H1047R mutantion can phosphorylate Akt and activate downstream pathways to promote the survival and expansion of tumor cells.

Catalog No

V0439

Reactivity

Human

Application

IHC,WB

Modification

Unmodified/ Total

Source

Monoclonal Mouse

Storage and Stability

Stable at -20°C for at least 1 year.

Other Name

5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha, 5-bisphosphate 3-kinase catalytic subunit alpha isoform, caPI3K, CLOVE, CWS5, MCAP, MCM, MCMTC, MGC142161, MGC142163, p110 alpha, p110alpha, Phosphatidylinositol 3 kinase catalytic alpha polypeptide, Phosphatidylinositol 3 kinase catalytic 110 KD alpha, Phosphatidylinositol 4 5 bisphosphate 3 kinase catalytic subunit alpha, Phosphatidylinositol 4 5 bisphosphate 3 kinase catalytic subunit alpha isoform, Phosphatidylinositol 4,5 bisphosphate 3 kinase 110 kDa catalytic subunit alpha, Phosphatidylinositol-4, Phosphoinositide 3 kinase catalytic alpha polypeptide, PI 3 Kinase catalytic subunit alpha, PI3 kinase p110 subunit alpha, PI3-kinase subunit alpha, PI3K, PI3K-alpha, PI3KC A, PIK3C A, Pik3ca, PK3CA, PK3CA_HUMAN, PtdIns 3 kinase p110, PtdIns-3-kinase subunit alpha, PtdIns-3-kinase subunit p110-alpha, Serine/threonine protein kinase PIK3CA

Gene Name

PIK3CA

UniProtKB

P42336

Clone ID

ABT454

Isotype

IgG2b, kappa

Localization

Cytoplasmic

Positive Tissue Control

Gastric adenocarcinoma with PIK3CA H1047R protein expression