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Akt (Phospho-Thr308) Antibody

Catalog No : A7005
  • Reactivity
  • Applications
    WB,IHC-p,IF(paraffin section),ELISA
  • Modification
    Phospho Specific
  • Source
    Polyclonal Rabbit
  • Storage and Stability
    -20°C/1 year
  • Size
    50 μl
  • Price/Quantity
  • Quantity
  • Product Name
    Akt (Phospho-Thr308) Antibody
  • Description
    The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2011]
  • Catalog No
  • Reactivity
    Human, Mouse, Rat, Monkey
  • Applications
    WB, IHC-p, IF(paraffin section), ELISA
  • Modification
    Phospho Specific
  • Source
    Polyclonal Rabbit
  • Dilution
    Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.
  • Purification
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Concentration
    1 mg/ml
  • Storage and Stability
    -20°C/1 year
  • Other Name
    AKT1; PKB; RAC; RAC-alpha serine/threonine-protein kinase; Protein kinase B; PKB; Protein kinase B alpha; PKB alpha; Proto-oncogene c-Akt; RAC-PK-alpha; AKT2; RAC-beta serine/threonine-protein kinase; Protein kinase Akt-2; Protein kinase B
  • Molecular Weight (Da)
  • Gene Name
  • Protein Name
    RAC-alpha serine/threonine-protein kinase/RAC-beta serine/threonine-protein kinase/RAC-gamma serine/threonine-protein kinase
  • Human Gene ID
  • Human Swiss Prot No.
  • Immunogen
    The antiserum was produced against synthesized peptide derived from human Akt around the phosphorylation site of Thr308. AA range:276-325
  • Specificity
    Phospho-Akt (T308) Polyclonal Antibody detects endogenous levels of Akt protein only when phosphorylated at T308.
  • Formulation
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.