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Primary Antibodies
SREBP-1 Antibody
SREBP-1 Antibody

Assay Biotechnology Inc Antibodies and ELISA Kits have been rigorously validated for laboratory grade quality results. High specificity paired with high affinity for targets of interest give researchers an advantage with our products

Catalog No: C10578
Reactivity:Human,Mouse,Rat,Golden hamster
Applications:WB,IHC,IF,ELISA
Modification:Unmodified/Total
Source:Polyclonal,Rabbit,IgG
Storage and Stability:Store at -20°C/1 year

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SREBP-1 Antibody

Western Blot analysis of 1,mouse-liver 2,hela 3,mouse-brain cells using primary antibody diluted at 1:1000(4°C overnight). Secondary antibody:Goat Anti-rabbit IgG IRDye 800( diluted at 1:5000, 25°C, 1 hour)

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Product Details
Product Name
SREBP-1 Antibody
Description
This gene encodes a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family. This gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Mar 2016],
Catalog No
C10578
Reactivity
Human, Mouse, Rat, Golden hamster
Source
Polyclonal, Rabbit,IgG
Modification
Unmodified/Total
Applications
WB, IHC, IF, ELISA
Dilution
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Storage and Stability
Store at -20°C/1 year
Other Name
Sterol regulatory element-binding protein 1 (SREBP-1) (Class D basic helix-loop-helix protein 1) (bHLHd1) (Sterol regulatory element-binding transcription factor 1) [Cleaved into: Processed sterol regulatory element-binding protein 1]
Molecular Weight (Da or kDa)
Gene Name
SREBF1 BHLHD1 SREBP1
Protein Name
SREBP-1
Human Gene ID
6720
Human Swiss Prot No.
P36956
Immunogen
Synthesized peptide derived from human SREBP-1. at AA range: 250-330
Specificity
This antibody detects endogenous levels of SREBP-1
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Publications (7)
Oat Fiber Modulates Hepatic Circadian Clock via Promoting Gut Microbiota-Derived Short Chain Fatty Acids. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY J Agr Food Chem. 2021;69(51):15624–15635 WB Mouse 1:1000 Liver

Author: Available in link provided

Date of Publication : Available in link provided

Effects of Metformin Combined with Lactoferrin on Lipid Accumulation and Metabolism in Mice Fed with High-Fat Diet. Nutrients Nutrients. 2018 Nov;10(11):1628 WB Mouse 1:500 Liver tissue

Author: Available in link provided

Date of Publication : Available in link provided

Investigation of the Lipid-Lowering Mechanisms and Active Ingredients of Danhe Granule on Hyperlipidemia Based on Systems Pharmacology. Frontiers in Pharmacology Front Pharmacol. 2020 May;0:528 WB Golden hamster 1:1000 Liver

Author: Available in link provided

Date of Publication : Available in link provided

Apical papilla stem cell-derived exosomes regulate lipid metabolism and alleviate inflammation in the MCD-induced mouse NASH model BIOCHEMICAL PHARMACOLOGY Yi-Fei Nie WB Mouse 1:1000 liver tissue

Author: Available in link provided

Date of Publication : Available in link provided

Chlormequat chloride induces hepatic steatosis by promoting mTOR/SREBP1 mediated lipogenesis via AMPK inhibition FOOD AND CHEMICAL TOXICOLOGY Chengping Kang WB Rat,Human liver tissue HepG2 cell

Author: Available in link provided

Date of Publication : Available in link provided

Time-restricted feeding ameliorates non-alcoholic fatty liver disease through modulating hepatic nicotinamide metabolism via gut microbiota remodeling Gut Microbes Ruijia Feng WB Mouse,Human 1:1000 liver tissue HepG2 cell

Author: Available in link provided

Date of Publication : Available in link provided

Fatty acid synthesis is indispensable for Kupffer cells to eliminate bacteria in ALD progression Hepatology Communications Xie Liuyu WB Mouse RAW 264.7 cell

Author: Available in link provided

Date of Publication : Available in link provided

Primary Antibodies

    • ELISA Kits

    • Research Areas

    Cell Adhesion Proteins Cell Cycle Proteins Channel Proteins Exosome GDP/GTP Binding Proteins Growth Factors and Hormones Homeodomain Proteins Immunohistochemical Kinases and Phosphatases Signaling

     

    Membrane Receptors Neurobiology Signaling Intermediates Steroid Receptors Structural Proteins Synthesis and Degradation Transcription Regulators Transport and Trafficking Tumor Suppressors/Apoptosis
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