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Primary Antibodies
P-glycoprotein 1 Antibody
P-glycoprotein 1 Antibody

Assay Biotechnology Inc Antibodies and ELISA Kits have been rigorously validated for laboratory grade quality results. High specificity paired with high affinity for targets of interest give researchers an advantage with our products

Catalog No: R12-2304
Reactivity:Human,Mouse,Rat
Applications:WB,IHC,IF,ELISA
Modification:Unmodified/Total
Source:Polyclonal,Rabbit,IgG
Storage and Stability:Store at -20°C/1 year

$205
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P-glycoprotein 1 Antibody

Immunohistochemistry analysis of Mdr-1 antibody in paraffin-embedded human brain tissue.

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Product Details
Product Name
P-glycoprotein 1 Antibody
Description
The membrane-associated protein encoded byThis gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance.The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. [provided by RefSeq, Jul 2008],
Catalog No
R12-2304
Reactivity
Human, Mouse, Rat
Source
Polyclonal, Rabbit,IgG
Modification
Unmodified/Total
Applications
WB, IHC, IF, ELISA
Dilution
WB 1:500-2000 IHC 1:100 - 1:300. ELISA: 1:40000. IF 1:50-200
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Storage and Stability
Store at -20°C/1 year
Other Name
p-pg; ABCB1; MDR1; PGY1; Multidrug resistance protein 1; ATP-binding cassette sub-family B member 1; P-glycoprotein 1; CD antigen CD243
Molecular Weight (Da or kDa)
141kD
Gene Name
ABCB1
Protein Name
Multidrug resistance protein 1
Human Gene ID
5243
Human Swiss Prot No.
P08183
Immunogen
The antiserum was produced against synthesized peptide derived from human P-glycoprotein 1. AA range:534-583
Specificity
P-glycoprotein 1 Polyclonal Antibody detects endogenous levels of P-glycoprotein 1 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Publications (3)
Enhanced autophagy reveals vulnerability of P-gp mediated epirubicin resistance in triple negative breast cancer cells. APOPTOSIS Apoptosis. 2016 Apr;21(4):473-488 WB Human MDA-MB-231 cell

Author: Available in link provided

Date of Publication : Available in link provided

Caveolin-1 affects tumor drug resistance in esophageal squamous cell carcinoma by regulating expressions of P-gp and MRP1. TUMOR BIOLOGY Tumor Biol. 2016 Jul;37(7):9189-9196 WB,IHC Human 1:100 esophageal squamous cell carcinoma tissues Ec9706 cell

Author: Available in link provided

Date of Publication : Available in link provided

The effect of ferroptosis - related proteins and histone deacetylases1 on neoadjuvant chemotherapy in breast cancer. Xiaoxia Wei IHC Human 1:100 breast cancer tissues

Author: Available in link provided

Date of Publication : Available in link provided

Primary Antibodies

    • ELISA Kits

    • Research Areas

    Cell Adhesion Proteins Cell Cycle Proteins Channel Proteins Exosome GDP/GTP Binding Proteins Growth Factors and Hormones Homeodomain Proteins Immunohistochemical Kinases and Phosphatases Signaling

     

    Membrane Receptors Neurobiology Signaling Intermediates Steroid Receptors Structural Proteins Synthesis and Degradation Transcription Regulators Transport and Trafficking Tumor Suppressors/Apoptosis
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