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PIK3CA H1047R (ABT453) PathoELITE™ Mouse mAb
PIK3CA H1047R (ABT453) PathoELITE™ Mouse mAb

Assay Biotechnology Inc Antibodies and ELISA Kits have been rigorously validated for laboratory grade quality results. High specificity paired with high affinity for targets of interest give researchers an advantage with our products

Catalog No: YM6978
Reactivity:Human
Applications:Immunohistochemistry (IHC)
Modification:Not Modified
Source:Mouse
Storage and Stability:Store at -20°C/1 year

$95
Product Details
Product Name
PIK3CA H1047R (ABT453) PathoELITE™ Mouse mAb
Description
The PIK3CA gene is located at 3Q26.3 and encodes a 124kDa protein. The protein is composed of 85kDa regulatory subunit and 110kDa catalytic subunit. The most common mutations of PIK3CA occur in exon 9 and exon 20. H1047R, one of the most common mutations occurs in exon 20. PIK3CA plays an important role in the PI3K/AKT/mTOR signaling pathway, which can be activated by this mutation, closely related to the occurrence of tumors and disease progression. In non-small cell lung cancer, H1047R mutantion can phosphorylate Akt and activate downstream pathways to promote the survival and expansion of tumor cells.
Catalog No
YM6978
Reactivity
Human
Source
Mouse
Modification
Not Modified
Applications
Immunohistochemistry (IHC)
Dilution
IHC 1:200-400, ELISA, 1:500-5000
Purification
The antibody was purified by affinity chromatography using a specific immunogen.
Storage and Stability
P42336
Human Swiss Prot No.
T-box transcription factor TBX21 (T-box protein 21) (T-cell-specific T-box transcription factor T-bet) (Transcription factor TBLYM)
Gene Name
T-bet
Protein Name
30009
Gene ID
TBX21 TBET TBLYM
Other Name
The antibody can specifically recognize the h1047r mutation of human PIK3CA protein, and does not react with wild-type PIK3CA protein.
Specificity
The antibody is provided in liquid form in phosphate-buffered saline with 50% glycerol, 0.05% BSA, and 0.05% Proclin 300.
Formulation
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