PIK3CA H1047R (PT0281R) PathoELITE™ Rabbit mAb

Assay Biotechnology Inc Antibodies and ELISA Kits have been rigorously validated for laboratory grade quality results. High specificity paired with high affinity for targets of interest give researchers an advantage with our products

Catalog No: YM7195R

Reactivity:Human

Applications:IHC

Modification:Not Modified

Source:Mouse

Storage and Stability:Store at -20°C/1 year

Size:

Price/Quantity $70

Quantity:

Datasheet

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PIK3CA H1047R (PT0281R) PathoELITE™ Rabbit mAb

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Product Details

Product Name

PIK3CA H1047R (PT0281R) PathoELITE™ Rabbit mAb

Description

The PIK3CA gene is located at 3Q26.3 and encodes a 124kDa protein. The protein is composed of 85kDa regulatory subunit and 110kDa catalytic subunit. The most common mutations of PIK3CA occur in exon 9 and exon 20. H1047R, one of the most common mutations occurs in exon 20. PIK3CA plays an important role in the PI3K/AKT/mTOR signaling pathway, which can be activated by this mutation, closely related to the occurrence of tumors and disease progression. In non-small cell lung cancer, H1047R mutantion can phosphorylate Akt and activate downstream pathways to promote the survival and expansion of tumor cells.

Catalog No

YM7195R

Reactivity

Human

Source

Mouse

Modification

Not Modified

Applications

IHC

Dilution

Ready to Use for Immunohistochemistry

Storage and Stability

Store at -20°C/1 year

Human Swiss Prot No.

P42336

Gene Name

PIK3CA

Protein Name

PIK3CA H1047R

Gene ID

5290

Other Name

5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha；5-bisphosphate 3-kinase catalytic subunit alpha isoform；caPI3K；CLOVE；CWS5；MCAP；MCM；MCMTC；MGC142161；MGC142163；p110 alpha；p110alpha；Phosphatidylinositol 3 kinase catalytic alpha polypeptide；Phosphatidylinositol 3 kinase catalytic 110 KD alpha；Phosphatidylinositol 4 5 bisphosphate 3 kinase catalytic subunit alpha；Phosphatidylinositol 4 5 bisphosphate 3 kinase catalytic subunit alpha isoform；Phosphatidylinositol 4,5 bisphosphate 3 kinase 110 kDa catalytic subunit alpha；Phosphatidylinositol-4；Phosphoinositide 3 kinase catalytic alpha polypeptide；PI 3 Kinase catalytic subunit alpha；PI3 kinase p110 subunit alpha；PI3-kinase subunit alpha；PI3K；PI3K-alpha；PI3KC A；PIK3C A；Pik3ca；PK3CA；PK3CA_HUMAN；PtdIns 3 kinase p110；PtdIns-3-kinase subunit alpha；PtdIns-3-kinase subunit p110-alpha；Serine/threonine protein kinase PIK3CA

Specificity

The antibody can specifically recognize the h1047r mutation of human PIK3CA protein, and does not react with wild-type PIK3CA protein.

Formulation

The antibody is provided in liquid form in phosphate-buffered saline with 50% glycerol, 0.05% BSA, and 0.05% Proclin 300.