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Primary Antibodies
Cyclin D1 (PT0238R) PT® Rabbit mAb
Cyclin D1 (PT0238R) PT® Rabbit mAb

Assay Biotechnology Inc Antibodies and ELISA Kits have been rigorously validated for laboratory grade quality results. High specificity paired with high affinity for targets of interest give researchers an advantage with our products

Catalog No: YM8149
Reactivity:Human,Mouse,Rat
Applications:WB,IHC,IF,IP,ELISA
Modification:Not Modified
Source:Rabbit IgG,Kappa
Storage and Stability:Store at -20°C/1 year

$190
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Recombinant Antibody
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Cyclin D1 (PT0238R) PT® Rabbit mAb

Various whole cell lysates were separated by 4-20% SDS-PAGE, and the membrane was blotted with anti-Cyclin D1 (PT0238R) antibody. The HRP-conjugated Goat anti-Rabbit IgG(H + L) antibody was used to detect the antibody. Lane 1: Mosue spleen Lane 2: Rat spleen Lane 3: LnCap Lane 4: MCF7 Predicted band size: 34kDa Observed band size: 36kDa

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Product Details
Product Name
Cyclin D1 (PT0238R) PT® Rabbit mAb
Description
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Alternative splicing results in multiple transcript variants encoding two different isoforms. The longer isoform acts as an apoptotic inhibitor and the shorter isoform acts as an apoptotic activator. [provided by RefSeq, Dec 2015],
Catalog No
YM8149
Reactivity
Human, Mouse, Rat
Source
Rabbit IgG, Kappa
Modification
Not Modified
Applications
WB,IHC,IF,IP,ELISA
Dilution
IHC 1:200-1:1000, WB 1:1000-1:5000, IF 1:200-1:1000, ELISA 1:5000-1:20000, IP 1:50-1:200
Purification
Protein A
Storage and Stability
Store at -20°C/1 year
Human Swiss Prot No.
P24385
Gene Name
CCND1
Protein Name
Cyclin D1
Gene ID
595
Other Name
CCND1;BCL1;PRAD1;G1/S-specific cyclin-D1;B-cell lymphoma 1 protein;BCL-1;BCL-1 oncogene;PRAD1 oncogene
Specificity
Endogenous
Formulation
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
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Publications (23)
Licoflavone A Suppresses Gastric Cancer Growth and Metastasis by Blocking the VEGFR-2 Signaling Pathway. Journal of Oncology2022;2022:5497991. Human 1 : 1000 MKN-45 cell

Author: Available in link provided

Date of Publication : Available in link provided

Targeting FoxM1 by thiostrepton inhibits growth and induces apoptosis of laryngeal squamous cell carcinoma. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY 2014 Nov 13 WB Human Hep-2 cell

Author: Available in link provided

Date of Publication : Available in link provided

The transcription factor FOXO4 is down-regulated and inhibits tumor proliferation and metastasis in gastric cancer. BMC CANCER Bmc Cancer. 2014 Dec;14(1):1-11 WB Human 1:1000 gastric cancer(GC) tissue

Author: Available in link provided

Date of Publication : Available in link provided

Chidamide Inhibits Acute Myeloid Leukemia Cell Proliferation by lncRNA VPS9D1-AS1 Downregulation via MEK/ERK Signaling Pathway. Frontiers in Pharmacology Front Pharmacol. 2020; 11: 569651 WB Human SKM-1 cell,THP-1 cell

Author: Available in link provided

Date of Publication : Available in link provided

Nigericin Exerts Anticancer Effects on Human Colorectal Cancer Cells by Inhibiting Wnt/β-catenin Signaling Pathway. MOLECULAR CANCER THERAPEUTICS Mol Cancer Ther. 2018 May;17(5):952-965 WB Human SW620 cell，KM12 cell

Author: Available in link provided

Date of Publication : Available in link provided

Final-2 targeted glycolysis mediated apoptosis and autophagy in human lung adenocarcinoma cells but failed to inhibit xenograft in nude mice. FOOD AND CHEMICAL TOXICOLOGY Food Chem Toxicol. 2019 Aug;130:1 WB Human A549 cell,SK-MEL-28 cell

Author: Available in link provided

Date of Publication : Available in link provided

Dietary sulforaphane inhibits histone deacetylase activity in B16 melanoma cells. Journal of Functional Foods 2015 Jul 28 WB Human,Mouse B16 melanoma cell,U251 cell

Author: Available in link provided

Date of Publication : Available in link provided

Endothelin-1 Activates the Notch Signaling Pathway and Promotes Tumorigenesis in Giant Cell Tumor of the Spine. SPINE Spine. 2019 Sep;44(17):E1000-E1009 WB Human 1:500 giant cell tumor (GCT) tissue

Author: Available in link provided

Date of Publication : Available in link provided

Effect of metformin on apoptosis, cell cycle arrest migration and invasion of A498 cells. Molecular Medicine Reports 2014 Mar 31 WB Human A498 cell

Author: Available in link provided

Date of Publication : Available in link provided

5,6-Dihydroxy-3,7,4′-trimethoxyflavonol induces G2/M cell cycle arrest and apoptosis in human hepatocellular carcinoma cells. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH J Asian Nat Prod Res. 2016;18(11):1079-1090 WB Human 1:1000 HepG-2 cell

Author: Available in link provided

Date of Publication : Available in link provided

Panobinostat reverses HepaCAM gene expression and suppresses proliferation by increasing histone acetylation in prostate cancer. GENE Gene. 2022 Jan;808:145977 WB Human LNCaP cell，DU145 cell

Author: Available in link provided

Date of Publication : Available in link provided

†, Ya-Yun Xu†, Gan Qin, Jiang-Qun Cheng and Fei-Hu Chen." Chemicals in the Environment and Brain Development: Importance of Neuroendocrinological Approaches (2017): 138.

Author: Available in link provided

Date of Publication : Available in link provided

Final-2 targeted glycolysis mediated apoptosis and autophagy in human lung adenocarcinoma cells but failed to inhibit xenograft in nude mice. FOOD AND CHEMICAL TOXICOLOGY Food Chem Toxicol. 2019 Aug;130:1 WB Human A549 cell,SK-MEL-28 cell

Author: Available in link provided

Date of Publication : Available in link provided

Effect of Fumonisin B1 on Proliferation and Apoptosis of Intestinal Porcine Epithelial Cells Toxins Tianjie Wang WB Pig

Author: Available in link provided

Date of Publication : Available in link provided

Voacamine is a novel inhibitor of EGFR exerting oncogenic activity against colorectal cancer through the mitochondrial pathway PHARMACOLOGICAL RESEARCH Sanjun Shi WB Human

Author: Available in link provided

Date of Publication : Available in link provided

FGF12 regulates cell cycle gene expression and promotes follicular granulosa cell proliferation through ERK phosphorylation in geese. Xingyong Chen WB Geese 1:1000 granulosa cell

Author: Available in link provided

Date of Publication : Available in link provided

Bruceine A: Suppressing metastasis via MEK/ERK pathway and invoking mitochondrial apoptosis in triple-negative breast cancer. BIOMEDICINE & PHARMACOTHERAPY Jun Lu WB Mouse,Human 1:1000 MDA-MB-231 cell,4T1 cell

Author: Available in link provided

Date of Publication : Available in link provided

L-Theanine delays D-galactose-induced senescence by regulating the cell cycle and inhibiting apoptosis in rat intestinal cells JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE Wei Xu WB Rat 1:2000 IEC-6 cell

Author: Available in link provided

Date of Publication : Available in link provided

Tafazzin mediates tamoxifen resistance by regulating cellular phospholipid composition in ER-positive breast cancer CANCER GENE THERAPY Li Xuan WB Human 1:1000 MCF7 cell,ZR-75-1 cell

Author: Available in link provided

Date of Publication : Available in link provided

4-Hydroxy-2-pyridone derivatives with antitumor activity produced by mangrove endophytic fungus Talaromyces sp. CY-3 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY Wencong Yang WB Human 1:1000 A549 cell,H1703 cell

Author: Available in link provided

Date of Publication : Available in link provided

L-theanine protects against D-galactose-induced aging in L6 skeletal muscle cells Journal of Functional Foods Min Long WB Rat 1:2000 L6 cell

Author: Available in link provided

Date of Publication : Available in link provided

Deficiency of smooth muscle cell ILF3 alleviates intimal hyperplasia via HMGB1 mRNA degradation-mediated regulation of the STAT3/DUSP16 axis JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY Ya-min Hou IHC Mouse neointima tissue

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Date of Publication : Available in link provided

Exosomes Derived from Adipose Mesenchymal Stem Cells Promote Regeneration of Injured Liver in Minipigs INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Yue Wang WB Pig 1:1000 liver tissue

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Primary Antibodies

    • ELISA Kits

    • Research Areas

    Cell Adhesion Proteins Cell Cycle Proteins Channel Proteins Exosome GDP/GTP Binding Proteins Growth Factors and Hormones Homeodomain Proteins Immunohistochemical Kinases and Phosphatases Signaling

     

    Membrane Receptors Neurobiology Signaling Intermediates Steroid Receptors Structural Proteins Synthesis and Degradation Transcription Regulators Transport and Trafficking Tumor Suppressors/Apoptosis
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