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Primary Antibodies
CDKN2A/p14ARF (PT0154R) Rabbit mAb
CDKN2A/p14ARF (PT0154R) Rabbit mAb

Assay Biotechnology Inc Antibodies and ELISA Kits have been rigorously validated for laboratory grade quality results. High specificity paired with high affinity for targets of interest give researchers an advantage with our products

Catalog No: YM8091
Reactivity:Human
Applications:WB,IF,IP,ELISA
Modification:Unmodified/ Total
Source:Rabbit Monoclonal
Storage and Stability:Store at -20°C/1 year

$190
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Recombinant Antibody
Sample Sized mAbs (Code: 5477)
Buy 1 Get 1 (Code: B1G1)
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CDKN2A/p14ARF (PT0154R) Rabbit mAb

Various whole cell lysates were separated by 4-20% SDS-PAGE, and the membrane was blotted with anti-CDKN2A/p14ARF (PT0154R) antibody. The HRP-conjugated Goat anti-Rabbit IgG(H + L) antibody was used to detect the antibody. Lane 1: Hela Lane 2: PC-3 Predicted band size: 14kDa Observed band size: 16kDa

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Product Details
Product Name
CDKN2A/p14ARF (PT0154R) Rabbit mAb
Description
CDKN2A generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by CDKN2A, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. CDKN2A is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene.
Catalog No
YM8091
Reactivity
Human
Source
Monoclonal Rabbit IgG, Kappa
Modification
Unmodified/ Total
Applications
WB,IF,IP,ELISA
Dilution
WB 1:1000-1:5000 IF 1:200-1:1000 ELISA 1:5000-1:20000 IP 1:50-1:200
Purification
Protein A
Storage and Stability
Store at -20°C/1 year
Human Swiss Prot No.
Q8N726
Gene Name
CDKN2A
Protein Name
Cyclin-dependent kinase inhibitor 2A isoform 4
Gene ID
1029
Other Name
CDKN2A;CDKN2;MLM;Cyclin-dependent kinase inhibitor 2A; isoform 4;p14ARF;p19ARF
Specificity
Endogenous
Formulation
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
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Primary Antibodies

    • ELISA Kits

    • Research Areas

    Cell Adhesion Proteins Cell Cycle Proteins Channel Proteins Exosome GDP/GTP Binding Proteins Growth Factors and Hormones Homeodomain Proteins Immunohistochemical Kinases and Phosphatases Signaling

     

    Membrane Receptors Neurobiology Signaling Intermediates Steroid Receptors Structural Proteins Synthesis and Degradation Transcription Regulators Transport and Trafficking Tumor Suppressors/Apoptosis
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