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Primary Antibodies
NLRP3 (PT0049R) PT® Rabbit mAb
NLRP3 (PT0049R) PT® Rabbit mAb

Assay Biotechnology Inc Antibodies and ELISA Kits have been rigorously validated for laboratory grade quality results. High specificity paired with high affinity for targets of interest give researchers an advantage with our products

Catalog No: YM8024
Reactivity:Human,Mouse,Rat
Applications:WB,IHC,IF,IP,ELISA
Modification:Not Modified
Source:Rabbit IgG,Kappa
Storage and Stability:Store at -20°C/1 year

$190
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Recombinant Antibody
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NLRP3 (PT0049R) PT® Rabbit mAb

Various whole cell lysates were separated by 4-20% SDS-PAGE, and the membrane was blotted with anti-NLRP3 (PT0049R) antibody. The HRP-conjugated Goat anti-Rabbit IgG(H + L) antibody was used to detect the antibody. Lane 1: J774A.1 Lane 2: RAW364.7 Lane 3: THP-1 Predicted band size: 118kDa Observed band size: 118kDa

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Product Details
Product Name
NLRP3 (PT0049R) PT® Rabbit mAb
Description
The protein encoded by this gene belongs to the glutamine synthetase family. It catalyzes the synthesis of glutamine from glutamate and ammonia in an ATP-dependent reaction. This protein plays a role in ammonia and glutamate detoxification, acid-base homeostasis, cell signaling, and cell proliferation. Glutamine is an abundant amino acid, and is important to the biosynthesis of several amino acids, pyrimidines, and purines. Mutations in this gene are associated with congenital glutamine deficiency, and overexpression of this gene was observed in some primary liver cancer samples. There are six pseudogenes of this gene found on chromosomes 2, 5, 9, 11, and 12. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014],
Catalog No
YM8024
Reactivity
Human, Mouse, Rat
Source
Rabbit IgG, Kappa
Modification
Not Modified
Applications
WB,IHC,IF,IP,ELISA
Dilution
IHC 1:200-1:1000, WB 1:500-1:5000, IF 1:200-1:1000, ELISA 1:5000-1:20000, IP 1:50-1:200
Purification
Protein A
Storage and Stability
Store at -20°C/1 year
Human Swiss Prot No.
Q96P20
Gene Name
NLRP3
Protein Name
NLRP3
Gene ID
114548
Other Name
NLRP3;C1orf7;CIAS1;NALP3;PYPAF1;NACHT, LRR and PYD domains-containing protein 3;Angiotensin/vasopressin receptor AII/AVP-like;Caterpiller protein 1.1CLR1.1;Cold autoinflammatory syndrome 1 protein;Cryopyrin;PYRIN-containing APAF1-like protein 1
Specificity
Endogenous
Formulation
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
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Publications (22)
Gynostemma pentaphyllum polysaccharides ameliorate non-alcoholic steatohepatitis in mice associated with gut microbiota and the TLR2/NLRP3 pathway Frontiers in Endocrinology Rui-Rui Wang IHC Mouse

Author: Available in link provided

Date of Publication : Available in link provided

Gut-Flora-Dependent Metabolite Trimethylamine-N-Oxide Promotes Atherosclerosis-Associated Inflammation Responses by Indirect ROS Stimulation and Signaling Involving AMPK and SIRT1 Nutrients Wenjian Ma WB Human

Author: Available in link provided

Date of Publication : Available in link provided

IL-37 alleviates TNF-α-induced pyroptosis of rheumatoid arthritis fibroblast-like synoviocytes by inhibiting the NF-κB/GSDMD signaling pathway IMMUNOBIOLOGY Qiang Shu IHC Human synovial tissue

Author: Available in link provided

Date of Publication : Available in link provided

Hypoxic preconditioned mesenchymal stem cells ameliorate rat brain injury after cardiopulmonary resuscitation by suppressing neuronal pyroptosis. Feng Chen WB Rat cortical tissue

Author: Available in link provided

Date of Publication : Available in link provided

miR-20b attenuates airway inflammation by regulating TXNIP and NLRP3 inflammasome in ovalbumin-induced asthmatic mice. Yun Sun IF Mouse 1:100 Lung tissue

Author: Available in link provided

Date of Publication : Available in link provided

Induced Neural Stem Cells Suppressed Neuroinflammation by Inhibiting the Microglial Pyroptotic Pathway in Intracerebral Hemorrhage Rats. Xueyun Liang IF Rat,Human 1:200 brain tissue induced neural stem cells (iNSCs)

Author: Available in link provided

Date of Publication : Available in link provided

Targeting the mechanism of IRF3 in sepsis-associated acute kidney injury via the Hippo pathway. Xingui Dai WB Human HK-2 cell

Author: Available in link provided

Date of Publication : Available in link provided

Pristimerin suppresses AIM2 inflammasome by modulating AIM2-PYCARD/ASC stability via selective autophagy to alleviate tendinopathy. Autophagy Xiao Yu WB Mouse Achilles tendon Peritoneal macrophages

Author: Available in link provided

Date of Publication : Available in link provided

A novel drug combination of Tofacitinib and Iguratimod alleviates rheumatoid arthritis and secondary osteoporosis. INTERNATIONAL IMMUNOPHARMACOLOGY Qiang Shu IHC，IF Rat 1:100，1:100 Synovial tissue,bone tissue

Author: Available in link provided

Date of Publication : Available in link provided

Yueliang Yin Ameliorates Endometrial Receptivity in Mice with Embryo Implantation Failure by Reducing Pyroptosis and Activating BDNF/TrkB Pathway. MOLECULAR NUTRITION & FOOD RESEARCH Ting Wang WB Mouse uterus

Author: Available in link provided

Date of Publication : Available in link provided

Piceatannol alleviates liver ischaemia/reperfusion injury by inhibiting TLR4/NF-κB/NLRP3 in hepatic macrophages. EUROPEAN JOURNAL OF PHARMACOLOGY Jian Du IHC，IF，WB Mouse 1:100,1:50,1:1000 liver tissue macrophages

Author: Available in link provided

Date of Publication : Available in link provided

Chlorogenic acid protects against myocardial ischemia–reperfusion injury in mice by inhibiting Lnc Neat1/NLRP3 inflammasome-mediated pyroptosis. Scientific Reports Deqin Lu IHC Mouse cardiomyocytes

Author: Available in link provided

Date of Publication : Available in link provided

Nobiletin Alleviated Epithelial–Mesenchymal Transition of Hepatocytes in Liver Fibrosis Based on Autophagy—Hippo/YAP Pathway MOLECULAR NUTRITION & FOOD RESEARCH Yuting Hao WB Mouse,Human liver tissue L02 cell

Author: Available in link provided

Date of Publication : Available in link provided

Dihydroxyacetone phosphate accumulation leads to podocyte pyroptosis in diabetic kidney disease JOURNAL OF CELLULAR AND MOLECULAR MEDICINE Zongwei Zhang WB Mouse kidney tissue podocytes

Author: Available in link provided

Date of Publication : Available in link provided

Cathepsin B aggravates atherosclerosis in ApoE-deficient mice by modulating vascular smooth muscle cell pyroptosis through NF-κB / NLRP3 signaling pathway PLoS One Hui Li IHC,WB Mouse 1:200 aorta tissue vascular smooth muscle cells (VSMCs)

Author: Available in link provided

Date of Publication : Available in link provided

Maresin-1 ameliorates hypertensive vascular remodeling through its receptor LGR6 MedComm Zheng Yin WB Mouse,Rat aorta tissue rat aortic smooth muscle cells (RASMCs)

Author: Available in link provided

Date of Publication : Available in link provided

PLD2 deletion ameliorates sepsis-induced cardiomyopathy by suppressing cardiomyocyte pyroptosis via the NLRP3/caspase 1/GSDMD pathway INFLAMMATION RESEARCH Li Jun IHC,WB Rat,Mouse 1:1000 heart tissue H9C2 cardiomyocytes

Author: Available in link provided

Date of Publication : Available in link provided

Exocarpium Citri Grandis ameliorates LPS-induced acute lung injury by suppressing inflammation, NLRP3 inflammasome, and ferroptosis JOURNAL OF ETHNOPHARMACOLOGY Zaibin Xu IF,WB Mouse Lung tissue RAW264.7 cell

Author: Available in link provided

Date of Publication : Available in link provided

Polystyrene nanoplastics induce intestinal and hepatic inflammation through activation of NF-κB/NLRP3 pathways and related gut-liver axis in mice SCIENCE OF THE TOTAL ENVIRONMENT Xuanwei Chen WB Mouse 1:1000 intestinal tissue,liver tissue

Author: Available in link provided

Date of Publication : Available in link provided

Dihydroartemisinin-driven TOM70 inhibition leads to mitochondrial destabilization to induce pyroptosis against lung cancer PHYTOTHERAPY RESEARCH Liu-Gen Li WB,IHC,IF Mouse,Human Lewis cell-Xenograft Lewis cell,A549 cell

Author: Available in link provided

Date of Publication : Available in link provided

Astaxanthin alleviates fibromyalgia pain and depression via NLRP3 inflammasome inhibition BIOMEDICINE & PHARMACOTHERAPY Lin Zhao WB Mouse 1:1000 brain tissue,spinal cord tissue

Author: Available in link provided

Date of Publication : Available in link provided

Ethyl pyruvate alleviates NLRP3/Caspase-1/GSDMD-mediated neuronal pyroptosis in neonatal rats with hypoxic–ischemic brain damage INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE Sha Sha WB Rat,Mouse 1:1000 hippocampal tissue HT22 cell

Author: Available in link provided

Date of Publication : Available in link provided

Primary Antibodies

    • ELISA Kits

    • Research Areas

    Cell Adhesion Proteins Cell Cycle Proteins Channel Proteins Exosome GDP/GTP Binding Proteins Growth Factors and Hormones Homeodomain Proteins Immunohistochemical Kinases and Phosphatases Signaling

     

    Membrane Receptors Neurobiology Signaling Intermediates Steroid Receptors Structural Proteins Synthesis and Degradation Transcription Regulators Transport and Trafficking Tumor Suppressors/Apoptosis
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