endoglin(ENG) Homo sapiens. This gene encodes a homodimeric transmembrane protein which is a major glycoprotein of the vascular endothelium. This protein is a component of the transforming growth factor beta receptor complex and it binds to the beta1 and beta3 peptides with high affinity. Mutations in this gene cause hereditary hemorrhagic telangiectasia, also known as Osler-Rendu-Weber syndrome 1, an autosomal dominant multisystemic vascular dysplasia. This gene may also be involved in preeclampsia and several types of cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2013],
Catalog No
N0100
Reactivity
Human
Applications
WB,IHC-p,IF/ICC,FCM,ELISA
Modification
Unmodfied/ Total
Source
Monoclonal Mouse
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/200 - 1/1000. Immunofluorescence: 1/200 - 1/1000. Flow cytometry: 1/200 - 1/400. ELISA: 1/10000. Not yet tested in other applications.
Purification
Affinity purification
Concentration
Storage and Stability
-20°C/1 year
Other Name
ENG; END; Endoglin; CD antigen CD105
Molecular Weight (Da)
Gene Name
ENG
Protein Name
Endoglin
Human Gene ID
2022
Human Swiss Prot No.
P17813
Immunogen
Purified recombinant fragment of human CD105 expressed in E. Coli.
Specificity
CD105 Monoclonal Antibody detects endogenous levels of CD105 protein.
Immunofluorescence analysis of HepG2 cells using CD105 Monoclonal Antibody (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.
Immunohistochemistry analysis of paraffin-embedded kidney cancer tissues (left) and stomach cancer tissues (right) with DAB staining using CD105 Monoclonal Antibody.
