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Primary Antibodies
Bcl-2 Monoclonal Antibody(6B5)
Bcl-2 Monoclonal Antibody(6B5)

Assay Biotechnology Inc Antibodies and ELISA Kits have been rigorously validated for laboratory grade quality results. High specificity paired with high affinity for targets of interest give researchers an advantage with our products

Catalog No: N1305
Reactivity:Human,Mouse,Rat,chicken
Applications:IF/ICC,WB,IHC-p
Modification:Unmodfied/ Total
Source:Monoclonal Mouse
Storage and Stability:-20°C/1 year

$160
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Bcl-2 Monoclonal Antibody(6B5)

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Product Details
Product Name
Bcl-2 Monoclonal Antibody(6B5)
Description
BCL2, apoptosis regulator(BCL2)Homo sapiens. This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016],
Catalog No
N1305
Reactivity
Human,Mouse,Rat,chicken
Applications
IF/ICC,WB,IHC-p
Modification
Unmodfied/ Total
Source
Monoclonal Mouse
Dilution
IF: 1:50-200 WB: 1:1000~2000 IHC: 1:200
Purification
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Concentration
Storage and Stability
-20°C/1 year
Other Name
BCL2; Apoptosis regulator Bcl-2
Molecular Weight (Da)
26266
Gene Name
BCL2
Protein Name
Apoptosis regulator Bcl-2
Human Gene ID
596
Human Swiss Prot No.
P10415
Immunogen
Synthetic Peptide of Bcl-2
Specificity
The antibody detects endogenous Bcl-2 proteins.
Formulation
PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.
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Publications (27)
Periostin promotes nucleus pulposus cells apoptosis by activating the Wnt/β-catenin signaling pathway

Author: Daxue Zhu, Zhaoheng Wang, Guangzhi Zhang, Congwen Ma, Xiaoming Qiu, Yidian Wang, Mingqiang Liu, Xudong Guo, Haiwei Chen, Qiang Deng, Xuewen Kang

Date of Publication : 2022-06-23

Inhibition of Ciliogenesis Enhances the Cellular Sensitivity to Temozolomide and Ionizing Radiation in Human Glioblastoma Cells

Author: Li WEI, Wei MA, Hui CAI, Shao Peng PENG, Huan Bing TIAN, Ju Fang WANG, Lan GAO, Jin Peng HE

Date of Publication : 2022-06-10

Long noncoding RNA CEBPA-DT promotes cisplatin chemo-resistance through CEBPA/BCL2 mediated apoptosis in oral squamous cellular cancer

Author: Xue Qiao, Jiayi Liu, Li Zhu, Rongbo Song, Ming Zhong, Yan Guo

Date of Publication : 2021-09-27

Increased hemoglobin and heme in MALDI-TOF MS analysis induce ferroptosis and promote degeneration of herniated human nucleus pulposus

Author: Shan, Liang, Xu, Ximing, Zhang, Jing, Cai, Peng, Gao, Han, Lu, Yingjie, Shi, Jiangang, Guo, Yinlong, Su, Yue

Date of Publication : 2021-09-08

Emodin Alleviates Intestinal Barrier Dysfunction by Inhibiting Apoptosis and Regulating the Immune Response in Severe Acute Pancreatitis

Author: Zhou Qi, Xiang Hong, Liu Han, Qi Bing, Shi Xueying, Guo Wenhui, Zou Jiacheng, Wan Xueting, Wu Wenjing, Wang Zhengpeng, Liu Wenhui, Xia Shilin, Shang Dong

Date of Publication : 2021-09-01

Omega‑3 polyunsaturated fatty acids inhibit IL‑11/STAT3 signaling in hepatocytes during acetaminophen hepatotoxicity

Author: Yunzhi Liu, Jingmin Lin, Yu Chen, Zhuonan Li, Jia Zhou, Xiao Lu, Zhengliang Chen, Daming Zuo

Date of Publication : 2021-08-17

A preparation of Ginkgo biloba L. leaves extract inhibits the apoptosis of hippocampal neurons in post-stroke mice via regulating the expression of Bax/Bcl-2 and Caspase-3

Author: Zhixiong Li, Guangxu Xiao, Huanyi Wang, Shuang He, Yan Zhu

Date of Publication : 2021-07-31

Astragaloside IV Attenuates the Myocardial Injury Caused by Adriamycin by Inhibiting Autophagy

Author: Luo Li-Fei, Qin Lu-Yun, Wang Jian-Xin, Guan Peng, Wang Na, Ji En-Sheng

Date of Publication : 2021-05-24

Mesenchymal stem cell-conditioned medium improved mitochondrial function and alleviated inflammation and apoptosis in non-alcoholic fatty liver disease by regulating SIRT1

Author: Mengmeng Yang, Yixin Cui, Jia Song, Chen Cui, Lingshu Wang, Kai Liang, Chuan Wang, Sha Sha, Qin He, Huiqing Hu, Xinghong Guo, Nan Zang, Lei Sun, Li Chen

Date of Publication : 2021-02-09

Myeloid NEMO deficiency promotes tumor immunosuppression partly via MCP1-CCR2 axis

Author: Li Yuanyuan, Liu Yakun, Li Zhongyao, Yi Le, Duan Weisong, Guo Moran, Bu Hui, Li Chunyan

Date of Publication : 2021-01-08

Sustained high expression of NRF2 and its target genes induces dysregulation of cellular proliferation and apoptosis is associated with arsenite-induced malignant transformation of human bronchial epithelial cells

Author: Qi Kong, Hanyi Deng, Chunchun Li, Xiaojuan Wang, Yasuyo Shimoda, Shasha Tao, Koichi Kato, Jie Zhang, Kenzo Yamanaka, Yan An

Date of Publication : 2020-11-20

Hydroxysafflor Yellow A Attenuates Hydrogen Peroxide-Induced Oxidative Damage on Human Umbilical Vein Endothelial Cells

Author: Xie Yuefeng, Guo Yan, Cao ShiDong, Xue Miaomiao, Fan ZhaoYue, Gao ChengXian, Jin Bo

Date of Publication : 2020-11-04

Knockdown of IKKβ Inhibits Tumor Development in a Leptomeningeal Metastasis Mouse Model and Proliferation of Lung Cancer Cells

Author: Yakun Liu, Yuanyuan Li, Zhongyao Li, Chunyan Li, Junying He, Hui Bu

Date of Publication : 2020-07-20

Tanshinone IIA mediates SMAD7-YAP interaction to inhibit liver cancer growth by inactivating the transforming growth factor beta signaling pathway

Author: Lifang Ma, Hongyuan Jiang, Xin Xu, Congcong Zhang, Yongjie Niu, Zhixian Wang, Yuquan Tao, Yan Li, Feng Cai, Xiao Zhang, Xinghe Wang, Yongchun Yu

Date of Publication : 2019-11-11

miR-125a-5p inhibits tumorigenesis in hepatocellular carcinoma

Author: Xin Xu, Yuquan Tao, Yongjie Niu, Zhixian Wang, Congcong Zhang, Yongchun Yu, Lifang Ma

Date of Publication : 2019-09-17

The Effect of SPTLC2 on Promoting Neuronal Apoptosis is Alleviated by MiR-124-3p Through TLR4 Signalling Pathway

Author: Su, Xinhong, Ye, Yuqin, Yang, Yongxiang, Zhang, Kailiang, Bai, Wei, Chen, Huijun, Kang, Enming, Kong, Chuiguang, He, Xiaosheng

Date of Publication : 2019-08-01

MiR-15b is a key regulator of proliferation and apoptosis of chondrocytes from patients with condylar hyperplasia by targeting IGF1, IGF1R and BCL2

Author: P. Cao, Y. Feng, M. Deng, J. Li, H. Cai, Q. Meng, W. Fang, Y. Li, J. Ke, X. Long

Date of Publication : 2018-12-03

The role of insulin-like growth factor 1 in ALS cell and mouse models: A mitochondrial protector

Author: Di Wen, Can Cui, Weisong Duan, Wan Wang, Ying Wang, Yakun Liu, Zhongyao Li, Chunyan Li

Date of Publication : 2018-11-08

Mesenchymal stem cell-derived extracellular vesicles promote apoptosis in RSC96 Schwann cells through the activation of the ERK pathway

Author: Dan Zhou, Wei Zhai, Miaomiao Zhang

Date of Publication : 2018-11-01

Huaier Augmented the Chemotherapeutic Sensitivity of Oxaliplatin via Downregulation of YAP in Hepatocellular Carcinoma

Author: Yuquan Tao, Liang Shan, Xin Xu, Hongyuan Jiang, Rui Chen, Zijun Qian, Zongguo Yang, Bin Liang, Haiyin Zheng, Feng Cai, Yongchun Yu, Lifang Ma

Date of Publication : 2018-10-10

Specific inhibitor of Notch‑3 enhances the sensitivity of NSCLC cells to gemcitabine

Author: Bi‑Dan Hu, Jia Guo, Yuan‑Zi Ye, Ting Du, Chun‑Song Cheng, Qian Jiang, Ruo‑Nan Liu, Yan‑Bei Zhang

Date of Publication : 2018-07-01

Systemic administration of scAAV9-IGF1 extends survival in SOD1G93A ALS mice via inhibiting p38 MAPK and the JNK-mediated apoptosis pathway

Author: Wan Wang, Di Wen, Weisong Duan, Juntao Yin, Can Cui, Ying Wang, Zhongyao Li, Yakun Liu, Chunyan Li

Date of Publication : 2018-02-27

Resveratrol ameliorates autophagic flux to promote functional recovery in rats after spinal cord injury

Author: Peng Wang, Lizhu Jiang, Nian Zhou, Hao Zhou, Huzhe Liu, Wenrui Zhao, Hanxiang Zhang, Xiang Zhang, Zhenming Hu

Date of Publication : 2018-01-03

Huaier Restrains Proliferative and Migratory Potential of Hepatocellular Carcinoma Cells Partially Through Decreased Yes-Associated Protein 1

Author: Liang Shan, Yan Li, Hongyuan Jiang, Yuquan Tao, Zijun Qian, Lan Li, Feng Cai, Lifang Ma, Yongchun Yu

Date of Publication : 2017-11-06

Synergistic Effect of Notch-3-Specific Inhibition and Paclitaxel in Non-Small Cell Lung Cancer (NSCLC) Cells Via Activation of The Intrinsic Apoptosis Pathway

Author: Fenglian He, Ting Du, Qian Jiang, Yanbei Zhang

Date of Publication : 2017-08-03

Intrathecal Delivery of ssAAV9-DAO Extends Survival in SOD1G93A ALS Mice

Author: Wang, Wan, Duan, Weisong, Wang, Ying, Wen, Di, Liu, Yakun, Li, Zhongyao, Hu, Haojie, Cui, Hongying, Cui, Can, Lin, Huiqian, Li, Chunyan

Date of Publication : 2016-12-26

scAAV9-VEGF prolongs the survival of transgenic ALS mice by promoting activation of M2 microglia and the PI3K/Akt pathway

Author: Ying Wang, Weisong Duan, Wan Wang, Di Wen, Yaling Liu, Yakun Liu, Zhongyao Li, Haojie Hu, Huiqian Lin, Can Cui, Dongxiao Li, Hui Dong, Chunyan Li

Date of Publication : 2016-07-05

Primary Antibodies

    • ELISA Kits

    • Research Areas

    Cell Adhesion Proteins Cell Cycle Proteins Channel Proteins Exosome GDP/GTP Binding Proteins Growth Factors and Hormones Homeodomain Proteins Immunohistochemical Kinases and Phosphatases Signaling

     

    Membrane Receptors Neurobiology Signaling Intermediates Steroid Receptors Structural Proteins Synthesis and Degradation Transcription Regulators Transport and Trafficking Tumor Suppressors/Apoptosis
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