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Caspase-8 Monoclonal Antibody(2G12)
Caspase-8 Monoclonal Antibody(2G12)

Assay Biotechnology Inc Antibodies and ELISA Kits have been rigorously validated for laboratory grade quality results. High specificity paired with high affinity for targets of interest give researchers an advantage with our products

Catalog No: N1510
Reactivity:Human,Mouse,Rat
Applications:WB,IF/ICC,IHC-p
Modification:Unmodfied/ Total
Source:Monoclonal Mouse
Storage and Stability:-20°C/1 year

$160
Product Details
Product Name
Caspase-8 Monoclonal Antibody(2G12)
Description
caspase 8(CASP8)Homo sapiens. This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alt
Catalog No
N1510
Reactivity
Human,Mouse,Rat
Applications
WB,IF/ICC,IHC-p
Modification
Unmodfied/ Total
Source
Monoclonal Mouse
Dilution
WB: 1:1000-2000 IHC:1:200-500 IF 1:200
Purification
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
Concentration
Storage and Stability
-20°C/1 year
Other Name
CASP8; MCH5; Caspase-8; CASP-8; Apoptotic cysteine protease; Apoptotic protease Mch-5; CAP4; FADD-homologous ICE/ced-3-like protease; FADD-like ICE; FLICE; ICE-like apoptotic protease 5; MORT1-associated ced-3 homolog; MACH
Molecular Weight (Da)
Gene Name
CASP8
Protein Name
Caspase8
Human Gene ID
841
Human Swiss Prot No.
Q14790
Immunogen
Recombinant Protein of Caspase-8
Specificity
The antibody detects endogenous Caspase-8 protein.
Formulation
PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.
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