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Primary Antibodies
TGFβ1 Antibody
TGFβ1 Antibody

Assay Biotechnology Inc Antibodies and ELISA Kits have been rigorously validated for laboratory grade quality results. High specificity paired with high affinity for targets of interest give researchers an advantage with our products

Catalog No: C0340
Reactivity:Human,Mouse,Rat
Applications:WB,IHC,IF,ELISA
Modification:Unmodified/Total
Source:Polyclonal,Rabbit,IgG
Storage and Stability:Store at -20°C/1 year

$205
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TGFβ1 Antibody

Immunofluorescence analysis of mouse-lung tissue. 1,TGFβ1 Polyclonal Antibody(red) was diluted at 1:200(4°C,overnight). 2, Cy3 labled Secondary antibody was diluted at 1:300(room temperature, 50min).3, Picture B: DAPI(blue) 10min. Picture A:Target. Picture B: DAPI. Picture C: merge of A+B

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Product Details
Product Name
TGFβ1 Antibody
Description
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGFB family members. This encoded protein regulates cell proliferation, differentiation and growth, and can modulate expression and activation of other growth factors including interferon gamma and tumor necrosis factor alpha. This gene i
Catalog No
C0340
Reactivity
Human, Mouse, Rat
Source
Polyclonal, Rabbit,IgG
Modification
Unmodified/Total
Applications
WB, IHC, IF, ELISA
Dilution
WB 1:500 - 1:2000. IHC: 1:100-300 ELISA: 1:20000. IF 1:100-300 Not yet tested in other applications.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Storage and Stability
Store at -20°C/1 year
Other Name
TGFB1; TGFB; Transforming growth factor beta-1; TGF-beta-1
Molecular Weight (Da or kDa)
Gene Name
TGFB1 TGFB
Protein Name
Transforming growth factor beta-1, TGF-β1, TGF b
Human Gene ID
7040
Human Swiss Prot No.
P01137
Immunogen
The antiserum was produced against synthesized peptide derived from human TGF beta1. AA range:336-385
Specificity
TGFβ1 Polyclonal Antibody detects endogenous levels of TGFβ1 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Publications (27)
Knockdown of SOX9 alleviates tracheal fibrosis through the Wnt/β-catenin signaling pathway

Author: Available in link provided

Date of Publication : Available in link provided

Motor neurons transplantation alleviates neurofibrogenesis during chronic degeneration by reversibly regulating Schwann cells epithelial-mesenchymal transition

Author: Available in link provided

Date of Publication : Available in link provided

7,8-Dihydroxyflavone alleviates cardiac fibrosis by restoring circadian signals via downregulating Bmal1/Akt pathway

Author: Available in link provided

Date of Publication : Available in link provided

PRL-3 facilitates Hepatocellular Carcinoma progression by co-amplifying with and activating FAK. Theranostics Theranostics. 2020; 10(22): 10345–10359 IHC Human 1 : 200 Liver,HCC tissue

Author: Available in link provided

Date of Publication : Available in link provided

Liposomal honokiol promotes hair growth via activating Wnt3a/β-catenin signaling pathway and down regulating TGF-β1 in C57BL/6N mice. BIOMEDICINE & PHARMACOTHERAPY Biomed Pharmacother. 2021 Sep;141:111793 WB,IHC Mouse 1:500,1:1000 Skin

Author: Available in link provided

Date of Publication : Available in link provided

Overexpression of miR‐200b inhibits the cell proliferation and promotes apoptosis of human hypertrophic scar fibroblasts in vitro. JOURNAL OF DERMATOLOGY WB Human hHSFs cell

Author: Available in link provided

Date of Publication : Available in link provided

Cigarette smoke extract induces the epithelial-to-mesenchymal transition via the PLTP/TGF-β1/Smad2 pathway in RLE-6TN cells. Toxicology Research Toxicol Res-Uk. 2017 Mar;6(2):215-222 WB Rat RLE-6TN cell

Author: Available in link provided

Date of Publication : Available in link provided

Nicousamide protects kidney podocyte by inhibiting the TGFβ receptor II phosphorylation and AGE-RAGE signaling. American Journal of Translational Research Am J Transl Res. 2017; 9(1): 115–125 WB Rat Kidney

Author: Available in link provided

Date of Publication : Available in link provided

Glycated albumin triggers fibrosis and apoptosis via an NADPH oxidase/Nox4-MAPK pathway-dependent mechanism in renal proximal tubular cells. MOLECULAR AND CELLULAR ENDOCRINOLOGY Mol Cell Endocrinol. 2015 Apr;405:74 WB Rat 1:1000 NRK-52E cell

Author: Available in link provided

Date of Publication : Available in link provided

Inhibin B suppresses anoikis resistance and migration through the transforming growth factor‐β signaling pathway in nasopharyngeal carcinoma. CANCER SCIENCE Cancer Sci. 2018 Nov;109(11):3416-3427 WB Human HNE1 cell， 5-8F cell

Author: Available in link provided

Date of Publication : Available in link provided

A Negative Feedback Loop Between NAMPT and TGF-β Signaling Pathway in Colorectal Cancer Cells. OncoTargets and Therapy Oncotargets Ther. 2021; 14: 187–198 ELISA Human HCT116 cell, Caco2 cell

Author: Available in link provided

Date of Publication : Available in link provided

Epidermal growth factor receptor signaling mediates aldosterone-induced profibrotic responses in kidney. EXPERIMENTAL CELL RESEARCH 2016 Jun 16 WB Rat 1:1500 kidney

Author: Available in link provided

Date of Publication : Available in link provided

AGEs-RAGE axis causes endothelial-to-mesenchymal transition in early calcific aortic valve disease via TGF-β1 and BMPR2 signaling. EXPERIMENTAL GERONTOLOGY 2020 Sep 07 WB Mouse Aortic valve tissue

Author: Available in link provided

Date of Publication : Available in link provided

Effect of montelukast combined with methylprednisolone for the treatment of mycoplasma pneumonia:. JOURNAL OF INTERNATIONAL MEDICAL RESEARCH 2019 May 09 FC Human T cell

Author: Available in link provided

Date of Publication : Available in link provided

miR‑221 targets HMGA2 to inhibit bleomycin‑induced pulmonary fibrosis by regulating TGF‑β1/Smad3-induced EMT. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 2016 Aug 11 WB Human A549 cell,HBE cell

Author: Available in link provided

Date of Publication : Available in link provided

Protective effects of miR-25 against hypoxia/reoxygenation‑induced fibrosis and apoptosis of H9c2 cells. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE Int J Mol Med. 2016 Oct;38(4):1225-1234 WB Rat H9c2 cell

Author: Available in link provided

Date of Publication : Available in link provided

Zhang, Hong, et al. "Therapeutic potential of bixin in PM2. 5 particles-induced lung injury in an Nrf2-dependent manner." Free Radical Biology and Medicine 126 (2018): 166-176.

Author: Available in link provided

Date of Publication : Available in link provided

Pan, Ming-Ming, et al. "Inhibition of TGF-β1/Smad signal pathway is involved in the effect of Cordyceps sinensis against renal fibrosis in 5/6 nephrectomy rats." Food and chemical toxicology 58 (2013): 487-494.

Author: Available in link provided

Date of Publication : Available in link provided

Sestrin2 attenuates renal damage by regulating Hippo pathway in diabetic nephropathy CELL AND TISSUE RESEARCH Yonghong Shi WB Human,Mouse

Author: Available in link provided

Date of Publication : Available in link provided

Amelioration of Lung Fibrosis by Total Flavonoids of Astragalus via Inflammatory Modulation and Epithelium Regeneration AMERICAN JOURNAL OF CHINESE MEDICINE Min Li WB Human,Mouse lung tissues A549 cells

Author: Available in link provided

Date of Publication : Available in link provided

Injectable Polyzwitterionic Lubricant for Complete Prevention of Cardiac Adhesion MACROMOLECULAR BIOSCIENCE Jinghua Li WB,IF Rat cardiac NIH/3T3 fibroblasts

Author: Available in link provided

Date of Publication : Available in link provided

Mannosylated polydopamine nanoparticles alleviate radiation- induced pulmonary fibrosis by targeting M2 macrophages and inhibiting the TGF-β1/Smad3 signaling pathway. Yuhui Hao WB Mouse lung tissue

Author: Available in link provided

Date of Publication : Available in link provided

Reduction of Th2 inflammation and fibrosis in eosinophilic esophagitis in a murine model by citri reticulatae pericarpium. Mingsan Miao WB,IHC Mouse 1:1000 esophagus tissue

Author: Available in link provided

Date of Publication : Available in link provided

A Mammalian Conserved Circular RNA CircLARP1B Regulates Hepatocellular Carcinoma Metastasis and Lipid Metabolism Advanced Science Jingxin Li WB Human PLC cell

Author: Available in link provided

Date of Publication : Available in link provided

Targeted lung therapy with rosmarinic acid encapsulated in PLGA microspheres for radiation-induced pulmonary fibrosis JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY Yonglai Chen IHC,WB Mouse 1:200 Lung tissue

Author: Available in link provided

Date of Publication : Available in link provided

Resveratrol attenuates inflammation and fibrosis in rheumatoid arthritis-associated interstitial lung disease via the AKT/TMEM175 pathway Journal of Translational Medicine Liu Nannan WB Human,Mouse lung tissue MRC-5 cell

Author: Available in link provided

Date of Publication : Available in link provided

Inhibitory effects of Eplerenone on angiogenesis via modulating SGK1/TGF-β pathway in contralateral kidney of CKD pregnancy rats CELLULAR SIGNALLING Wenping Zhou IHC Rat 1:100 kidney tissue

Author: Available in link provided

Date of Publication : Available in link provided

Primary Antibodies

    • ELISA Kits

    • Research Areas

    Cell Adhesion Proteins Cell Cycle Proteins Channel Proteins Exosome GDP/GTP Binding Proteins Growth Factors and Hormones Homeodomain Proteins Immunohistochemical Kinases and Phosphatases Signaling

     

    Membrane Receptors Neurobiology Signaling Intermediates Steroid Receptors Structural Proteins Synthesis and Degradation Transcription Regulators Transport and Trafficking Tumor Suppressors/Apoptosis
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