ZAP-70 is a 70 kDa tyrosine protein kinase. It belongs to the Syk family. It is expressed in T cells and NK cells, but not in most normal mature B cells. It is involved in the activation of T cell receptors. The expression of ZAP-70 is related to the mutation status, disease progression and prognosis of Ig heavy chain variable region gene in patients with chronic lymphocytic leukemia, which can be used to judge the prognosis of CLL.
Catalog No
V0504
Reactivity
Human
Application
IHC,WB
Modification
Unmodified/ Total
Source
Monoclonal Mouse
Storage and Stability
Stable at -20°C for at least 1 year.
Other Name
70 kDa zeta associated protein, 70 kDa zeta-associated protein, EC 2.7.10.2, FLJ17670, FLJ17679, Selective T cell defect, SRK, STD, Syk related tyrosine kinase, Syk-related tyrosine kinase, Truncated ZAP kinase, Tyrosine protein kinase ZAP70, Tyrosine-protein kinase ZAP-70, TZK, ZAP 70, ZAP70, ZAP70_HUMAN, Zeta chain associated protein kinase 70kD, Zeta chain associated protein kinase 70 kDa, Zeta chain associated protein kinase 70 kDa isoform 1, Zeta chain associated protein kinase 70 kDa isoform 2, Zeta chain of T cell receptor associated protein kinase 70, Zeta chain TCR associated protein kinase 70kD, Zeta chain TCR associated protein kinase 70 kDa
Gene Name
ZAP70
UniProtKB
P43403
Clone ID
ABT246
Isotype
IgG1, kappa
Localization
Cytoplasmic, Nuclear
Positive Tissue Control
Tonsil/ Appendix
Specificity
The antibody can specifically recognize human ZAP-70 protein.In western blotting of Jurkat cell lysate, the antibody can label a 70 kDa band corresponding to ZAP-70.
