Description
CK20 is a cytokeratin with a molecular weight of 46 kDa, which is mainly expressed in gastrointestinal epithelium, urethral epithelium and Merkel cells. It is mainly used for the diagnosis of gastrointestinal adenocarcinoma, ovarian mucinous tumor, Merkel cell carcinoma and cholangiopancreatic adenocarcinoma. CK20 was negative in squamous cell carcinoma, lung adenocarcinoma, endometrial adenocarcinoma, breast cancer, small cell lung cancer and ovarian non mucinous tumor. It is often used in combination with CK7 and villin to judge the tissue source of adenocarcinoma.
Reactivity
Human, M
Application
IHC
Modification
Unmodified/ Total
Source
Monoclonal Mouse
Storage and Stability
Stable at -20°C for at least 1 year.
Other Name
CD20, CK 20, CK-20, CK20, Cytokeratin-20, Cytokeratin20, K1C20_HUMAN, K20, KA20, Keratin 20, keratin 20, type I, keratin 21, rat, homolog of, Keratin, Keratin type I cytoskeletal 20, Keratin-20, Keratin20, KRT 20, KRT 21, KRT20, KRT21, MGC35423, OTTHUMP00000164518, Protein IT, type I cytoskeletal 20
Gene Name
KRT20
UniProtKB
P35900
Clone ID
ABT413
Isotype
IgG1, Kappa
Localization
Cytoplasmic, Membranous
Positive Tissue Control
Colon/ Appendix
Specificity
The antibody can specifically recognize human CK20 protein, and shows no cross reaction with CK1, 5, 6, 7, 8, 13, 14, 15, 17, 18.
Formulation
PBS, pH7.2, 0.03% Proclin 300, 50% glycerol
