Description
CK19 is the smallest keratin with a molecular weight of 40-44 kDa. which is widely distributed in monolayer epithelial cells and many squamous epithelial tissues, and plays an important role in maintaining cell structure and morphology. Its function is related to cell proliferation, differentiation, invasion and metastasis, and cell cycle, etc. CK19 is an important biomarker of breast cancer cells, lymph nodes, peripheral blood and bone marrow tumor cells. The keratin of CK10 with molecular weight of about 60kD is not expressed in epidermal basal cells under normal conditions. When the cells generated by basal cell division undergo neoplasia, CK1 / CK10 begins to be expressed. The expression of CK10 is correlated with the differentiation degree of malignant keratinocytes, and the higher the positive expression in tissues, the stronger the differentiation represented by CK10.
Reactivity
Human
Application
IHC
Modification
Unmodified/ Total
Source
Monoclonal Mouse
Storage and Stability
Stable at -20°C for at least 1 year.
Other Name
40 kDa keratin intermediate filament, CK 19, CK-19, CK19, Cytokeratin 19, Cytokeratin-19, K19, K1C19_HUMAN, K1CS, Keratin 19, Keratin type I 40 kD, Keratin type I 40kD, Keratin type I cytoskeletal 19, Keratin, type I cytoskeletal 19, Keratin, type I, 40 kd, Keratin-19, KRT19, MGC15366
Gene Name
KRT19
UniProtKB
P08727
Clone ID
ABT505
Isotype
IgG1, Kappa
Localization
Cytoplasmic, Membranous
Positive Tissue Control
Kindey/ Skin
Specificity
The antibody can recognize human CK10 and CK19 protein, and shows no cross reaction with CK1, 5, 6, 7, 8, 13, 14, 15, 17, 18, 20.
Formulation
PBS, pH7.2, 0.03% Proclin 300, 50% glycerol
