CD105 is a homodimeric cell membrane glycoprotein linked by disulfide bonds. It is a new class of cell adhesion molecules and plays an important role in regulating angiogenesis. As a receptor of TGF-beta, CD105 is highly expressed in vascular endothelial cells of tumor related neovascular endothelium. Therefore, the evaluation of tumor microvessel density by immunohistochemical staining is significantly correlated with tumor invasion and prognosis.
The antibody can specifically recognize human CD105 protein. In western blotting of Hela, HepG2 and MCF7 cell lysates, there shows a 90 kDa band detected by the antibody.
Various whole cell lysates were separated by 8% SDS-PAGE, and the membrane was blotted with anti-CD105 antibody at 1ug/ml. The HRP-conjugated anti-Mouse
IgG antibody was used to detect the antibody.
Predicted band size: 70 kDa
Observed band size:100 kDa