There are two isoforms of progesterone receptor, PRA(94 kDa)PRB(114 kDa), which exist in normal endometrium and breast epithelial cells. Their function is to regulate the expression of genes as transcription factors and affect cytotoxic proliferation and differentiation. A large number of studies show that breast cancer patients with positive ER and PR have good endocrine therapy effect, high remission rate, low recurrence rate and good prognosis. Therefore, PR has been used as a routine examination item for breast cancer patients.
Catalog No
V0172
Reactivity
Human
Application
IHC
Modification
Unmodified/ Total
Source
Monoclonal Mouse
Storage and Stability
Stable at -20°C for at least 1 year.
Other Name
NR3C3, Nuclear receptor subfamily 3 group C member 3, PGR, PR, PRA, PRB, PRGR_HUMAN, Progesterone receptor, Progestin receptor form A, Progestin receptor form B
Gene Name
PGR
UniProtKB
P06401
Clone ID
ABT-PR.1
Isotype
IgG1, Kappa
Localization
Nuclear
Positive Tissue Control
Cervix/ Breast carcinoma tissue which weak positive staining
Specificity
The antibody can specifically recognize human PR protein, including PR-A and PR-B.
